Afatinib is an effective first-line treatment for patients with EGFR-mutant NSCLC. Research groups designed and synthesized afatinib analogs to increase the inhibitory effect against EGFR and VEGFR2/KDR kinases. Meo. OMe HN HN OMe Afatinib Compound I Compound II The researchers run a series of tests to explore the kinase inhibitory activity of Afatinib and Compound I with EGFR. They found the IC50 of Compound I is 3.6 nM and that of Afatinib is 1.6nM. a. Please briefly explain the effectiveness of Compound I compare to Afatinib based on the information given

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