A bioinformatics study revealed that the enzymes called vasoinhibins have a Cys-His-Ser catalytic triad. These enzymes regulate angiogenesis (the formation of new blood vessels) and are thus potential drug targets for cancer treatment. If the cysteine residue serves as the nucleophile, what are the possible roles of histidine and serine in enzyme catalysis?

A bioinformatics study revealed that the enzymes called vasoinhibins have a Cys-His-Ser catalytic triad. These enzymes regulate angiogenesis (the formation of new blood vessels) and are thus potential drug targets for cancer treatment. If the cysteine residue serves as the nucleophile, what are the possible roles of histidine and serine in enzyme catalysis?

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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