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A 43-year-old man is diagnosed with chronic myeloid leukemia (CML) and started on standard imatinib therapy (tyrosine kinase inhibitor, TKI). Which of the following clinical findings indicate this therapy protocol is NOT appropriate and should be altered? O Ph+ chromosome is undetectable in bone marrow cells after 9 months of treatment. O The BCR ABL1 (fusion) to ABL1 (wild-type) expression (MRNA) ratio is significantly reduced after 3 months of treatment. O The expression (MRNA) ratio of BCR-ABL1/ABL1 is down to 0.08% after 18 months of therapy. O 1-month into therapy and the patient shows an increased frequency of bone marrow cells with the Ph+ chromosome. O His WBC counts have returned to normal levels.

A 43-year-old man is diagnosed with chronic myeloid leukemia (CML) and started on standard imatinib therapy (tyrosine kinase inhibitor, TKI). Which of the following clinical findings indicate this therapy protocol is NOT appropriate and should be altered? O Ph+ chromosome is undetectable in bone marrow cells after 9 months of treatment. O The BCR ABL1 (fusion) to ABL1 (wild-type) expression (MRNA) ratio is significantly reduced after 3 months of treatment. O The expression (MRNA) ratio of BCR-ABL1/ABL1 is down to 0.08% after 18 months of therapy. O 1-month into therapy and the patient shows an increased frequency of bone marrow cells with the Ph+ chromosome. O His WBC counts have returned to normal levels.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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A 43 year-old man is diagnosed with chronic myeloid leukemia (CML) and started on standard imatinib therapy (tyrosine kinase inhibitor, TKI). Which of the following clinical findings indicate this therapy protocol is NOT appropriate and should be altered? O Ph+ chromosome is undetectable in bone marrow cells after 9 months of treatment. O The BCR ABL1 (fusion) to ABL1 (wild-type) expression (MRNA) ratio is significantly reduced after 3 months of treatment. O The expression (mRNA) ratio of BCR-ABL1/ABL1 is down to 0 08% after 18 months of therapy O 1-month into therapy and the patient shows an increased frequency of bone marrow cells with the Ph+ chromosome O His WBC counts have returned to normal levels.
Transcribed Image Text:A 43 year-old man is diagnosed with chronic myeloid leukemia (CML) and started on standard imatinib therapy (tyrosine kinase inhibitor, TKI). Which of the following clinical findings indicate this therapy protocol is NOT appropriate and should be altered? O Ph+ chromosome is undetectable in bone marrow cells after 9 months of treatment. O The BCR ABL1 (fusion) to ABL1 (wild-type) expression (MRNA) ratio is significantly reduced after 3 months of treatment. O The expression (mRNA) ratio of BCR-ABL1/ABL1 is down to 0 08% after 18 months of therapy O 1-month into therapy and the patient shows an increased frequency of bone marrow cells with the Ph+ chromosome O His WBC counts have returned to normal levels.
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