BIOLOGY
5th Edition
ISBN: 9781265202859
Author: BROOKER
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Chapter 9.2, Problem 2CS
Summary Introduction
To determine: The specific model for predicting the location of amino acid substitution for the prevention of the activation of receptors. The model that has to be labeled such that two Xs are at the place where glutamic acid can be found in the mutant receptor, and one Y should be at the place where no glutamic acid is found.
Introduction: The binding of the ligand with the enzyme-linked receptors is very important for the normal functioning of the cell. The binding of cells results in the activation of the enzyme-linked receptors.
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Dear Expert.
Thank you for your advice, which is good and helpful. I note that your answer is "when 3 binding sites have been occupied the activity of these receptors is maximum."
However, I also note that for a similar question (see below) on α7 nicotinic Acetylcholine Receptor (nAChR) also gives the same answer, ie. at least 3 agonist binding sites should be occupied.
Another Question - "To maximize the activity of an α7 nAChR, how many agonist binding sites should be occupied."
I understand that in α7 nAChR, binding to two sites is more effective and binding to three sites is most effective for activation. On the other hand, binding to four or five sites in the nAChRs of chromosome 7 speeds up desensitization more than activation.
Therefore, to maximize the activity of an α7 nicotinic Acetylcholine Receptor (nAChR) is also "3 sites".
Am I right?
How does a competitive binding assay determine the affinity for an agonist? Specifically, how is the competition measured and the number of receptors/ligands counted?
Ion channel-coupled receptors • G-protein-coupled receptors • Enzyme-linked receptors • Briefly describe what a G-protein is (explain by using the words GTPase, GTP and GDT) • Briefly describe how a G-protein-coupled receptor for the signal / information further into • Briefly describe how an enzyme-linked receptor carries the signal / information further into the cell.
Chapter 9 Solutions
BIOLOGY
Ch. 9.1 - Figure 9.1 Response of a yeast cell to glucose....Ch. 9.1 - Prob. 1CSCh. 9.1 - Which type of signal, paracrine or endocrine, is...Ch. 9.1 - Prob. 3CCCh. 9.2 - Prob. 1CSCh. 9.2 - Prob. 2CSCh. 9.2 - Prob. 1CCCh. 9.3 - Prob. 1CSCh. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CC
Ch. 9.3 - In the case of signaling pathways involving...Ch. 9.5 - Prob. 1EQCh. 9.5 - Prob. 2EQCh. 9.5 - Prob. 3EQCh. 9.5 - Prob. 1CCCh. 9 - Prob. 1TYCh. 9 - Prob. 2TYCh. 9 - Prob. 3TYCh. 9 - Prob. 4TYCh. 9 - Prob. 5TYCh. 9 - The relay protein Ras is part of the EGF pathway...Ch. 9 - Prob. 7TYCh. 9 - Prob. 8TYCh. 9 - Prob. 9TYCh. 9 - Prob. 10TYCh. 9 - Prob. 1CQCh. 9 - Conceptual Questions What are the three stages of...Ch. 9 - Prob. 3CQCh. 9 - Prob. 1COQCh. 9 - Prob. 2COQ
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- Exercise 5 Membrane receptors are proteins that are incorporated in the cytoplasmic membrane of a cell, allowing the detection of specific molecules such as (hormones, growth factor) and triggering a cascade of biochemical Synthesis of protein reactions. The adjacent schema represents the steps of the synthesis of these membrane receptors. 1. Label the structures from a to f. In order to study the biosynthesis and secretion of this protein (membrane receptors), a solution containing radioactive amino acid was injected in the blood of an animal. Samples of certain cells were taken at regular intervals of time. The intensity of radioactivity was measured in different cellular organelles. 2000 The table below represents the variations of the quantity of a membrane protein in different parts of the cell, as function of time. Time (min) 15 40 50 Structure X 26 12 2 1 Structure Z 0. 6. 10 6. Structure Y 0. 10 24 2. Represent the obtained results in the form 3. 3.1. Analyze the obtained…arrow_forwardmight Q2. Whydo we perform concentration-response curves rather than choosing a single concentration of agonist and testing it against a single concentration of antagonist?arrow_forwardPlease ASAP. Thankuarrow_forward
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