BIOLOGY
5th Edition
ISBN: 9781265202859
Author: BROOKER
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Chapter 9, Problem 8TY
Summary Introduction
Introduction: Ligands are important cellular molecules that conduct signals during any cellular activity. Different ligands have different cellular receptors which get activated by their respective ligand and the cellular process is initiated. The absence of the required ligand during a cellular process can prevent the cellular process from completing.
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Identify which of the following statements is a lie?
Select one:
a. The docking of ligands to the receptor causes receptor-associated proteins to activate another protein to continue the signaling cascade and one example of this event is the binding of epidermal growth factor (EGF) to the EGF receptor .
b. Ligands are important to initiate signal Transduction pathway.
c. Ligands detach from the cell surface receptor in order to change the conformation of the receptor and initiate the signaling pathway.
A small number of cell surface receptors and low amounts of signals (ligands) can generate a large intracellular response as each step of the signal transduction pathway can be expanded by...
A. gene amplification, i.e. increasing the number of target genes.
B. enzyme-mediated signal amplification, e.g. phosphorylation cascades.
C. the synthesis of new proteins.
D. ATP Synthase, e.g. by building proton (H+) gradients.
A biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and...
A. produce a cellular response by altering the Na+/K+ pump located near the receptor site.
B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response.
C. induce a change in the receptor molecule shape, which will ultimately produce a cellular response.
D. induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).
Chapter 9 Solutions
BIOLOGY
Ch. 9.1 - Figure 9.1 Response of a yeast cell to glucose....Ch. 9.1 - Prob. 1CSCh. 9.1 - Which type of signal, paracrine or endocrine, is...Ch. 9.1 - Prob. 3CCCh. 9.2 - Prob. 1CSCh. 9.2 - Prob. 2CSCh. 9.2 - Prob. 1CCCh. 9.3 - Prob. 1CSCh. 9.3 - Prob. 1CCCh. 9.3 - Prob. 2CC
Ch. 9.3 - In the case of signaling pathways involving...Ch. 9.5 - Prob. 1EQCh. 9.5 - Prob. 2EQCh. 9.5 - Prob. 3EQCh. 9.5 - Prob. 1CCCh. 9 - Prob. 1TYCh. 9 - Prob. 2TYCh. 9 - Prob. 3TYCh. 9 - Prob. 4TYCh. 9 - Prob. 5TYCh. 9 - The relay protein Ras is part of the EGF pathway...Ch. 9 - Prob. 7TYCh. 9 - Prob. 8TYCh. 9 - Prob. 9TYCh. 9 - Prob. 10TYCh. 9 - Prob. 1CQCh. 9 - Conceptual Questions What are the three stages of...Ch. 9 - Prob. 3CQCh. 9 - Prob. 1COQCh. 9 - Prob. 2COQ
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- Paracrine signaling is characterized by ligands that are a. produced by the cell itself. b. secreted by neighboring cells. c. present on the plasma membrane of neighboring cells. d. secreted by distant cells.arrow_forwardExplain the three stages of cell signaling. a. receptor b. transduction c. response. Attach imagesarrow_forwardWhat type of cell signaling receptor is depicted below a. Cytoplasmic Receptor b. Transmembrane Receptor c. Intracellular Receptor d. Nuclear Receptorarrow_forward
- Which of the following statements regarding signaling in normal cells and cancer cells is false? a. In normal cells, RTK transphosphorylation is strictly dependent on ligand binding. Ligand binding promotes a conformational change in the RTKS that is required for dimerization, and dimerization is required for transphosphorylation. b. Cancers cells that over-express RTK's can respond to tiny amounts of ligand, and in some instances signaling can be ligand-independent. c. Cancer cells that have established several autocrine signaling loops have a poor prognosis, because these cells have enabled multiple independent mitogenic signal transduction pathways. 4 d. The extracellular ectodomains of all RTKS are highly conserved in primary sequence and structure. e. RTKS have a hydrophilic extracellular ectodomain, and hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain, which contains the catalytic portion of the protein.arrow_forwardThe receptor-associated proteins called G proteins... A. bind GTP. B. can activate or inhibit an effector protein, e.g. adenyl cyclase. C. interact with membrane-associated proteins to influence their function. D. both a and b E. a, b, and carrow_forwarda universal feature of cell signaling receptors is that they? a. undergo a structural (shape) change when the signal molecule is bound b. are present only in the plasma membrane c. are only ion channels d. are protein kinases e. aer only nuclear receptorsarrow_forward
- Intracellular receptors bind to signaling molecules that are A. anionic. B. cationic. C. nonpolar. D. polypeptides.arrow_forwardIn a clinical study, it was found that copaiba essential oil positively regulated multiple signaling pathways in neuronal cells. These included the following signaling pathways which regulate neuronal metabolism, proliferation and immunity: (Select all that apply.) Choose at least one answer. a. AMPK b. pI3K/Akt/mTOR c. MAPK d. JAK/STATarrow_forwardCarbon monoxide is a deadly gas. This is due to its quick activation of specific signaling pathways in cells of our body. Since this is a gas, it most likely uses.... Select one: a. A transmembrane cell surface receptor since it cannot pass through cell membranes b. A voltage-gated ion channel receptor since it creates a charge when crossing the cell membrane c. An intracellular receptor since it can easily diffuse across a membranearrow_forward
- Lipid-soluble signaling molecules, such as testosterone, cross the membrane of all cells but only affect target cells because a. intracellular receptors are only present in target cells b. only target cells possess the cytosolic enzymes that transduce the testosterone c. target cells are the only cells that can initiate the phosphorylation cascade leading to the transcription factor d. only target cells retain the appropriate DNA segmentsarrow_forwardProteases are enzymes that destroy proteins. Application of these enzymes to an intact cell strips the proteins off the cell surface. If a specific signaling molecule is added to cells stripped of surface proteins and the cell still responds, what must be true of the signaling pathway? The receptor is a ligand-gated ion channel. The signaling molecule doesn't need a receptor. The signal can directly activate the second messenger system and does not need to activate the receptor. The receptor for this signal is inside the cell, and the signaling molecule is nonpolar and can diffuse into the cell.arrow_forwardWhich of the following elements may be in the transduction part of cell signaling? Select one: a. A phosphatase b. A kinase c. cyclin AMP d. ions e. All answers are correctarrow_forward
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