The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication. Introduction: Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Question

Want to see more full solutions like this?

Answer 1

Question

100%

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Students have asked these similar questions

Do sensory neurons express ACE2 or only neurolipin-1 receptors for COVID19 virus particle binding?

Explain the process of CNS infiltration of COVID19 through sensory neurons from beginning to end, including processes like endocytosis, the different receptors/proteins that are involved, how they are transported and released, etc.,

H2C CH2 HC-COOO CH2 ܘHO-C-13c-O isocitrate C-S-COA H213c CH2 C-OO 13C-S-COA CH2 C-00 the label will not be present in succinyl CoA C-S-COA succinyl-CoA

Answer 2

Question

100%

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 3

Question

100%

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 4

Question

100%

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Want to see more full solutions like this?

Subscribe now to access step-by-step solutions to millions of textbook problems written by subject matter experts!

Answer 5

Question

100%

Answer 6

Question

100%

Answer 7

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Answer 8

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Answer 9

Chapter 8, Problem 1Q

Summary Introduction

To review:

The production of a large amount of NADH (reduced form of nicotinamide adenine dinucleotide or NAD) leading to lactate accumulation in an individual, as a result of alcohol intoxication.

Introduction:

Alcohol is one of the most common mood-altering drugs used by individuals. However, alcohol is a toxic drug, which is capable of causing damage to liver tissues and in severe cases, death of the individual. Thus, the body has evolved certain mechanisms to reduce the damage through the oxidation of consumed alcohol (ethanol).

Answer 10

Expert Solution & Answer

Explanation of Solution

The metabolism of ethanol occurs in the liver of an individual. The oxidation of ethanol produces acetaldehyde, which is further oxidized to form acetic acid along with carbon dioxide and water. Further, both the oxidation processes result in the production of a large amount of NADH. This is because alcohol has no or negligible nutrient content and thus, cannot be stored in the body.

The NADH thus produced is utilized for the conversion of pyruvic acid to lactic acid (lactate) along with the production of NAD⁺ as a byproduct. The equation has been described below:

Pyruvate+NADH+H+→Lactate+NAD+

Hence, lactate or lactic acid accumulation is commonly observed as a side-effect of alcohol intoxication. Furthermore, synthesized NAD⁺ participates in the glycolysis reaction for the production of energy.

Answer 11

Expert Solution & Answer

Answer 12

Expert Solution & Answer

Answer 13

Conclusion

Therefore, it can be concluded that the fate of the NADH (that is, the conversion of pyruvate to lactate), which is formed as a result of oxidation of ethanol and acetaldehyde, leads to the accumulation of lactate in an individual.

Answer 14

Ch. 8 - Prob. 1Q Ch. 8 - Prob. 2Q Ch. 8 - Prob. 3Q Ch. 8 - Prob. 4Q Ch. 8 - Prob. 5Q Ch. 8 - Prob. 6Q Ch. 8 - Prob. 7Q Ch. 8 - Prob. 1RQ Ch. 8 - Prob. 2RQ Ch. 8 - Prob. 3RQ

Concept explainers

Videos

Explanation of Solution

Want to see more full solutions like this?

Chapter 8 Solutions