Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Textbook Question
Chapter 5, Problem 1Q
QUESTION: Why does the height of the spike get shorter after successive injections of ligand in Figure 5B-2a?
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Question 2
You are using molecular modelling software to examine the X-ray crystal structure of the
B2-adrenoceptor. You have access to two quality structural images of:
a B2-adrenoceptor bound to a full agonist (BI-167107), and
a B2-adrenoceptor bound to an inverse agonist (carazolol).
You would like to understand the nature and magnitude of the conformational changes made by the
B2-adrenoceptor as it moves from an inactive to active state.
Question 2a
What regions of the receptor would you expect to show the largest conformational changes?
Provide a rationale for your answer.
Question 2b
Describe how you could use information from the two X-ray crystal structures to determine what the
conformational changes are.
G protein-coupled receptors, such as the B2-adrenoceptor, normally only have a single C-terminus
end and a single N-terminus end. However, when examining the X-ray crystal structure of the B2-
adrenoceptor bound to the inverse agonist, there appear to be parts of the…
Drug 1-Ivacaftor (VX-770): Ivacaftor is a potentiator that increases CFTR channel opening time. We know from cell culture studies that this increases chloride transport by as much as 50% from baseline and restores it closer to what would be expected in wild type CFTR. Basically, the drug increases CFTR activity by unlocking the gate that allows for the normal flow of salt and fluids.
For which class of mutations do you think Ivacaftor will be most effective? Explain your choice.
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The following is a block diagram for a sphingoglycolipid
where the building blocks are labeled with letters and the
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A
1
2
B
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a. Which building blocks are fatty acid residues?
b. Which building blocks are carbohydrate residues?
c. Which linkages are amide linkages?
d. Which linkages could involve a monosaccharide?
Chapter 5 Solutions
Becker's World of the Cell (9th Edition)
Ch. 5 - How do phototrophs and chemotrophs depend...Ch. 5 - How does the spontaneity of a chemical reaction...Ch. 5 - QUESTION: Why does the height of the spike get...Ch. 5 - For a chemical reaction happening in a cell, what...Ch. 5 - Prob. 5.1PSCh. 5 - QUANTITATIVE Photosynthetic Energy Transduction....Ch. 5 - Energy Conversion. Most cellular activities...Ch. 5 - Problem Set Enthalpy, Entropy, and Free Energy....Ch. 5 - Violating the Second Law? The second law of...Ch. 5 - QUANTITATIVE The Equilibrium Constant. The...
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