Given the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism HN HO You OH NH₂ 20.PO HO HO HO OH. H₂N 20.,PO HO HO HO OH HO H₂N® 20.po HO HO HO OH Inhibitor 2-0,PO HO HO HO OH
Given the active site and reaction mechanism below, what is the mechanism of irreversible inhibition of the inhibitor provided? Active Site Reaction Mechanism HN HO You OH NH₂ 20.PO HO HO HO OH. H₂N 20.,PO HO HO HO OH HO H₂N® 20.po HO HO HO OH Inhibitor 2-0,PO HO HO HO OH
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Transcribed Image Text:Given the active site and reaction mechanism
below, what is the mechanism of irreversible
inhibition of the inhibitor provided?
Active Site
Reaction Mechanism
HN
20,PO
20 PO
HO
HO
YO+ OH
H₂N®
NH₂
20.PO
HO
HO
-O
HO OH
H₂N
HO
HO OH
HO
20.PO
HO
HO
HO OH
Inhibitor
20.PO
HO
HO
HO OH

Transcribed Image Text:○ Transition state analog
Uncompetitive
Mechanism-based
Affinity-based
O Non-specific
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