Human Physiology
Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 5, Problem 1aCP

Define the term glycolysis in terms of its initial substrates and products. Explain why there is a net gain of 2 molecules of ATP in this process.

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Summary Introduction

To review:

The definition of glycolysis in terms of its initial substrates and products along with the reason for the net gain of two molecules of ATP in the process.

Introduction:

Cellular respiration is a process in which energy is released by stepwise break down of glucose and other molecules through which energy is consumed, and some of this energy is used to produce ATP (adenosine triphosphate), that is, the energy currency for every cell. The complete combustion of a glucose molecule requires oxygen and yields about 38 ATP for each molecule of glucose. Some of the energy is produced in the absence of an oxygen requiring pathway that leads to the generation of lactic acid as an end product.

Explanation of Solution

The first cellular respiration process for the breakdown of glucose is glycolysis, which is a process of breakdown of glucose (a 6-carbon compound) into the two molecules of pyruvate or pyruvic acid (a 3-carbon compound). The diagram belowshows the different steps in the breakdown of glucose:

Human Physiology, Chapter 5, Problem 1aCP

Glycolysis is a 10-step process and in every step, enzymes are required to catalyze the reaction. The 6-carbon molecule is the substrate which results in the production of two molecules of 3-carbon pyruvic acid (pyruvate).

The pathway requires two ATP molecules as a source of energy, one for the conversion of glucose into glucose-6-phosphate and the second for the conversion of fructose-6-phosphate into the fructose-1,6-bisphosphate.

The glycolysis pathway generates 2 molecules of NADH (nicotinamide adenine dinucleotide hydrogen) and 4 molecules of ATP, 2 ATP molecules are expended during the process, so there is a net gain of 2 ATP molecules.

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Chapter 5 Solutions

Human Physiology

Ch. 5 - Prob. 6bCPCh. 5 - Describe transamination and deamination and...Ch. 5 - List five blood-borne energy carriers and explain,...Ch. 5 - Prob. 1RACh. 5 - In anaerobic metabolism, the oxidizing agent for...Ch. 5 - When skeletal muscles lack sufficient oxygen,...Ch. 5 - The conversion of lactic acid to pyruvic acid...Ch. 5 - Which of these statements about the oxygen in the...Ch. 5 - In terms of the number of ATP molecules directly...Ch. 5 - Ketone bodies are derived from Ch. 5 - Prob. 8RACh. 5 - The conversion of glucose 6-phosphate to free...Ch. 5 - The formation of glucose from pyruvic acid derived...Ch. 5 - Which of these organs has an almost absolute...Ch. 5 - When amino acids are used as an energy source, Ch. 5 - Intermediates formed during fatty acid metabolism...Ch. 5 - State the advantages and disadvantages of the...Ch. 5 - What purpose is served by the formation of lactic...Ch. 5 - Describe the effect of cyanide on oxidative...Ch. 5 - Describe the metabolic pathway by which glucose...Ch. 5 - Prob. 18RACh. 5 - Explain how energy is obtained from the metabolism...Ch. 5 - Prob. 20RACh. 5 - Why is the production of lactic acid termed a...Ch. 5 - Prob. 22RACh. 5 - What three molecules serve as the major substrates...Ch. 5 - A friend, wanting to lose weight, eliminates all...Ch. 5 - Suppose a drug is developed that promotes the...Ch. 5 - For many years, the total number of molecules of...Ch. 5 - People who are starving have very thin arms and...Ch. 5 - Prob. 28RACh. 5 - Prob. 29RACh. 5 - Prob. 30RACh. 5 - Prob. 31RACh. 5 - Prob. 32RACh. 5 - Prob. 33RA
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