Human Physiology
Human Physiology
15th Edition
ISBN: 9781259864629
Author: Fox, Stuart Ira
Publisher: Mcgraw-hill Education,
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Chapter 5, Problem 19RA

Explain how energy is obtained from the metabolism of amino acids. Why does a starving person have a high concentration of urea in the blood?

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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid is located on the outside of the soluble protein but not near an active site. O-H¨ A. What type of mutation occurred? O-H B. What 2 types of chemical bonds are found in the R-groups of each amino acid? The R groups are shaded. CH2 CH2 CH2 H2N-C-COOH H2N-C-COOH 1 H Glutamic acid H Aspartic acid C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules? D. Consider the chemical properties of the two amino acids and the location of the amino acid in the protein. Explain what effect this mutation will have on this protein's function and why.
engineered constructs that consist of hollow fibers are acting as synthetic capillaries, around which cells have been loaded. The cellular space around a single fiber can be modeled as if it were a Krogh tissue cylinder. Each fiber has an outside “capillary” radius of 100 µm and the “tissue” radius can be taken as 200 µm. The following values apply to the device:R0 = 20 µM/secaO2 = 1.35 µM/mmHgDO2,T = 1.67 x 10-5 cm2/secPO2,m = 4 x 10-3 cm/secInstead of blood inside the fibers, the oxygen transport and tissue consumption are being investigated by usingan aqueous solution saturated with pure oxygen. As a result, there is no mass transfer resistance in the synthetic“capillary”, only that due to the membrane itself. Rather than accounting for pO2 variations along the length ofthe fiber, use an average value in the “capillary” of 130 mmHg.Is the tissue fully oxygenated?

Chapter 5 Solutions

Human Physiology

Ch. 5 - Prob. 6bCPCh. 5 - Describe transamination and deamination and...Ch. 5 - List five blood-borne energy carriers and explain,...Ch. 5 - Prob. 1RACh. 5 - In anaerobic metabolism, the oxidizing agent for...Ch. 5 - When skeletal muscles lack sufficient oxygen,...Ch. 5 - The conversion of lactic acid to pyruvic acid...Ch. 5 - Which of these statements about the oxygen in the...Ch. 5 - In terms of the number of ATP molecules directly...Ch. 5 - Ketone bodies are derived from Ch. 5 - Prob. 8RACh. 5 - The conversion of glucose 6-phosphate to free...Ch. 5 - The formation of glucose from pyruvic acid derived...Ch. 5 - Which of these organs has an almost absolute...Ch. 5 - When amino acids are used as an energy source, Ch. 5 - Intermediates formed during fatty acid metabolism...Ch. 5 - State the advantages and disadvantages of the...Ch. 5 - What purpose is served by the formation of lactic...Ch. 5 - Describe the effect of cyanide on oxidative...Ch. 5 - Describe the metabolic pathway by which glucose...Ch. 5 - Prob. 18RACh. 5 - Explain how energy is obtained from the metabolism...Ch. 5 - Prob. 20RACh. 5 - Why is the production of lactic acid termed a...Ch. 5 - Prob. 22RACh. 5 - What three molecules serve as the major substrates...Ch. 5 - A friend, wanting to lose weight, eliminates all...Ch. 5 - Suppose a drug is developed that promotes the...Ch. 5 - For many years, the total number of molecules of...Ch. 5 - People who are starving have very thin arms and...Ch. 5 - Prob. 28RACh. 5 - Prob. 29RACh. 5 - Prob. 30RACh. 5 - Prob. 31RACh. 5 - Prob. 32RACh. 5 - Prob. 33RA
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