Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 35, Problem 29CTQ
Describe how long-term potentiation can lead to a nicotine addiction.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 35 Solutions
Biology 2e
Ch. 35 - Figure 35.3 Which of the following statements is...Ch. 35 - Figure 35.11 Potassium channel blockers, such as...Ch. 35 - Figure 35.26 Which of the following statements is...Ch. 35 - Neurons contain _____ which can receive_____...Ch. 35 - A(n)______neuron has one axon and one____ dendrite...Ch. 35 - Glia that provide myelin for neurons in the brain...Ch. 35 - Meningitis is a viral or bacterial infection of...Ch. 35 - For a neuron to fire an action potential, its...Ch. 35 - After an action potential, the opening of...Ch. 35 - What is the term for protein channels that connect...
Ch. 35 - Which of the following molecules is not involved...Ch. 35 - Thelobe contains the visual cortex frontal...Ch. 35 - Theconnects the two cerebral hemispheres. limbic...Ch. 35 - Neurons in Thecontrol motor reflexes. thalamus...Ch. 35 - Phineas Gage was a 19th century railroad worker...Ch. 35 - Activation of the sympathetic nervous system...Ch. 35 - Where are parasympathetic preganglionic cell...Ch. 35 - ______ is released by motor nerve endings onto...Ch. 35 - Parkinson’s disease is a caused by the...Ch. 35 - __________ medications are often used to treat...Ch. 35 - Strokes are often caused by. neurodegeneration...Ch. 35 - Why is it difficult to identify the cause of many...Ch. 35 - Why do many patients with neurodevelopmentaJ...Ch. 35 - How are neurons similar to other cells? How are...Ch. 35 - Multiple sclerosis causes demyelination of axons...Ch. 35 - Many neurons have only a single axon, but many...Ch. 35 - How does myelin aid propagation of an action...Ch. 35 - What are the main steps in chemical...Ch. 35 - Describe how long-term potentiation can lead to a...Ch. 35 - What methods can be used to determine the function...Ch. 35 - What are the main functions of the spinal cord?Ch. 35 - Alzheimer’s disease involves three of the four...Ch. 35 - What are the main differences between the...Ch. 35 - What are the main functions of the sensory somatic...Ch. 35 - Describe how the sensory-somatic nervous system...Ch. 35 - Scientists have suggested that the autonomic...Ch. 35 - What are the main symptoms of Alzheimer’s disease?Ch. 35 - What are possible treatments for patients with...
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