Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 30, Problem 13P
Interpretation Introduction
Interpretation:
The Shine-Dalgarno sequence and its role in the variation of the efficiency of initiation of the protein synthesis needs to be defined.
Concept Introduction:
Australian scientists Lynn Dalgarno and John Shine proposed the Shine-Dalgarno sequence. Usually situated 8 bases upstream of the initial codon AUG, it is the ribosomal binding site within the mRNA. This sequence is present both within archaea, as well as in bacteria, and exists in some mitochondrial and chloroplastic transcripts. The sequence of RNA supports recruiting the ribosome towards the mRNA to start protein synthesis via aligning the ribosome with the initial codon.
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Students have asked these similar questions
Given this mRNA strand: 3’ - AUGAGGAAGGUA - 5’; what are the components of the polypeptide?
What will be the overall anti-codon sequence in tRNA for this mRNA?
5’-GUAGCCUUAUCUAGCGAUCACCGUCCGUAUUACUAGUGGCCAGACUCUUUUCACCAUGUAUAGUUG-3’
The sequence below shows the non-coding strand from the
whole of the transcribed region of a very short gene.
5’-GGCTTCTTTAGTACTGGCCAGTGGGATCCAAGTAGGCTGCCATTTCGT-3’
Write out the sequence of the mRNA from this gene in the orientation 5′ → 3′ and, using the genetic code (see Fig. 1. overleaf) deduce the amino acid sequence of the peptide it encodes (NB you should read about the operation of the genetic code prior to attempting this question).
Chapter 30 Solutions
Biochemistry
Ch. 30 - Prob. 1PCh. 30 - Prob. 2PCh. 30 - The Second Genetic Code Review the evidence...Ch. 30 - Codon-Anticodon Recognition: Base-Pairing...Ch. 30 - Consequences of the Wobble Hypothesis Point out...Ch. 30 - Prob. 6PCh. 30 - Prob. 7PCh. 30 - Prob. 8PCh. 30 - Prob. 9PCh. 30 - The Consequences of Ribosome Complexity Eukaryotic...
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