Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 30, Problem 6P
Interpretation Introduction
Interpretation:
The number of codons that might mutate to become nonsense codons through the single base change should be determined along with the identification of encoded amino acids.
Concept Introduction:
Amino acids are compounds containing amino as well as acidic group. The general molecular structure of an amino acid is as follows:
Here, R is different group for different amino acids. If there is more than one amino group present in an amino acid, they are considered as basic amino acids and if there is more than one carboxylic group then they are considered as acidic amino acids.
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MRNA CODONS RESPONSIBLE
FOR LINING UP EACH OF THE 20 AMINO ACIDS
Code-End of the
Amino Acid
MRNA Codons*
(anticodon) tRNA
Alanine
GCU
AGA
Arginine
Asparagine
Aspartic Acid
Cysteine
Glutamic Acid
Glutamine
Glycine
Histidine
AAU
GAU
UGU
GAA
CAA
GGU
CAU
AUU
CUU
AAA
AUG
Isoleucine
Leucine
Lysine
Methionine
UUU
Phenylalanine
Proline
CCU
UCU
Serine
ACU
UGG
Threonine
Tryptophan
Tyrosine
Valine
UAU
GUA
There are 64 codons. Some amino acids have several mRNA codor
There is, however, no overlap of codes.
There are four codons that encode threonine. Consider the leader sequence in Figure 31.22A. What codons are used and with what frequency?
MRNA CODONS RESPONSIBLE
FOR LINING UP EACH OF THE 20 AMINO ACIDS
Amino Acid
Code-End of the
MRNA Codons*
(anticodon) tRNA
Alanine
GCU
Arginine
Asparagine
Aspartic Acid
Cysteine
Glutamic Acid
AGA
AAU
GAU
UGU
GAA
Glutamine
CAA
Glycine
Histidine
GGU
CAU
Isoleucine
AUU
Leucine
CUU
Lysine
Methionine
AAA
AUG
Phenylalanine
Proline
UUU
CCU
Serine
UCU
Threonine
ACU
Tryptophan
Tyrosine
Valine
UGG
UAU
GUA
* There are 64 codons. Some amino acids have several mRNA codons.
There is, however, no overlap of codes.
1. You should be able to fill in the 3-letter "code-end" of the tRNA
molecules in the table above. Remember, in RNA A pairs with U, and
G pairs with C. There is no thymine. Fill in the table.
Chapter 30 Solutions
Biochemistry
Ch. 30 - Prob. 1PCh. 30 - Prob. 2PCh. 30 - The Second Genetic Code Review the evidence...Ch. 30 - Codon-Anticodon Recognition: Base-Pairing...Ch. 30 - Consequences of the Wobble Hypothesis Point out...Ch. 30 - Prob. 6PCh. 30 - Prob. 7PCh. 30 - Prob. 8PCh. 30 - Prob. 9PCh. 30 - The Consequences of Ribosome Complexity Eukaryotic...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- What is the start codon? What are the stop codons? Do any of them code for amino acids?arrow_forwardCodons in the set CUU, CUC, CUA, and CUG all code for the amino acid leucine. In this set, the first and second bases are identical; the identity of the third base is irrelevant. For what other sets of codons is the third base also irrelevant? For what amino acid(s) does each set code?arrow_forwardFor each altered nucleotide sequence give the type of mutation (effect at the DNA/nucleotide level; see #1 above)arrow_forward
- UAA is a stop codon. Why does the UAA sequence in the segment of mRNA 5′-G-C-A-U-G-G-A-C-C-C-C-G-U-U-A-U-U-A-A-A-C-A-C-3′not cause protein synthesis to stop?arrow_forwardAccording to wobble rules, what codons should be recognized by the follow- ing anticodons? What amino acid residues do these correspond to? (а) 5' —1CC—3' (b) 5'-GCU-3'arrow_forwardIf the template strand of DNA carries the code: GGT-AAT-ACT, then what is the corresponding mRNA code? Recall that DNA does not use "U" as a base. Enter your answer below using the same format as shown here (three capital letters for each codon, separated by a single dash, no spaces, repeat for each codon). Table 26-1 The Genetic Code First Third Position Position (5'-end) Second Position (3'-end) U C A G Phe UAU UCU UCC Тyr Тyr Stop Stop UGU UGC Cys Cys Stop Trp UUU Ser U UUC Phe Ser UAC C UUA Leu UCA Ser UAA UGA A UUG Leu UCG Ser UAG UGG G Leu Leu Leu Leu CAU САС CAA CAG CUU CCU Pro Pro Pro Pro His His CGU Arg Arg Arg Arg U CỤC CỦA CUG CCC CCA CGC CGA C Gln Gln CCG CGG G Пе Thr ACU АСС ACA ACG AUU AAU Asn AGU Ser U AAC AAA AAG AUC Пе Thr Asn AGC Ser C AUA Ile Thr Lys Lys AGA AGG Arg Arg A A AUG* Met Thr GUU Val Val Val Val GCU GCC GCA GCG Ala GGU GGC GGA Gly Gly Gly Gly U C A GAU GỤC GUA GUG Asp Asp Glu Glu Ala GAC G Ala Ala GAA GAG GGG *AUG also serves as the principal initiation…arrow_forward
- According to wobble rules, what codons should be recognized by the following anticodons? What amino acid residues do these correspond to?(a) 5′ ¬ICC ¬ 3′ (b) 5′ ¬GCU ¬3′arrow_forwardA series of tRNAs have the following anticodons. Consider the wobble rules listed in Table and give all possible codons with which each tRNA can pair. Q. 5′ –AAG–3′arrow_forwardWhy is wobble tolerated in the third position of the codon but not in the first two?arrow_forward
- Using the Genetic Code Table in Figure 1.3, what is the proper sequence of amino acids in the polypeptide chain based from the given codons of MRNA (3' AAU GCC AGU GGU 5')? * U UUU Phe UCU) UC UCA UCG UAU] UAC Tyr UAA Stop UGA Stop A UAG Stop UGG Trp G UGU U UUC) UGC Cys Ser UUA Leu UUGJ CU) CCU CAU1 CGU His CUC CAC CAA CGC CC Leu CCA Pro Arg CUA CGA A Gin CUG) CG CAG CGG G AUU) ACU) AGU AAU1 Asn AAC, Thr AAA1 U AGC }Ser č A G AUC lle ACC A AUA J ACA AGA AUG Met ACG, AAG}Lys AGG Arg GGU GUU) GUC Val GCU) GCC GCA GCG J GAU1 Asp GACI Ala GGC GGA GGG ) G GUA Gly GAA1 GAG) A Glu GUG) G Figure 1.3 Alanine, Serine, Glycine, Asparagine Serine, Glycine, Asparagine, Alanine Glycine, Asparagine, Alanine, Serine Asparagine, Alanine, Serine, Glycinearrow_forward???????arrow_forwardOriginal sequence: Consider the following coding 71 nucleotide DNA template sequence (It does not contain a translational start): 5’-GTTTCCCCTATGCTTCATCACGAGGGCACTGACATGTGTAAACGAAATTCCAACCTGAGCGGCGT GTTGAG-3’ Question: 4) In a mutant you discovered that the underlined nucleotide has been deleted. What would the resulting peptide sequence be? What type of mutation is this? 5’-GTTTCCCCTATGCTTCATCACGAGGGCACTGACATGTGTAAACGAAATTCCAACCTGAGCGGCGT GTTGAG-3arrow_forward
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