Concept explainers
(a)
Interpretation:
The structural formula of the
Concept Introduction:
The Nucleotide consists of the Nitrogenous base, Sugar molecule and Phosphate ion. The Nitrogenous base and Sugar molecule are linked by β-N-glycosidic bond. The Sugar molecule and phosphate ion are linked by ester bond. The base and sugar molecule are said to be Nucleoside.
(b)
Interpretation:
The structural formula of the nucleotide Guanosine-
Concept Introduction:
The Nucleotide consists of the Nitrogenous base, Sugar molecule and Phosphate ion. The Nitrogenous base and Sugar molecule are linked by β-N-glycosidic bond. The Sugar molecule and phosphate ion are linked by ester bond. The base and sugar molecule are said to be Nucleoside.
(c)
Interpretation:
The structural formula of the nucleotide
Concept Introduction:
The Nucleotide consists of the Nitrogenous base, Sugar molecule and Phosphate ion. The Nitrogenous base and Sugar molecule are linked by β-N-glycosidic bond. The Sugar molecule and phosphate ion are linked by ester bond. The base and sugar molecule are said to be Nucleoside.
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Organic Chemistry
- Suppose that 28% of the nucleotides in a DNA molecule are deoxythymidine 5'-monophosphate, and that during DNA replication the percentage amounts of available nucleotide bases art 22% A, 22% C, 28% G. and 28% T. Which base would be depleted first in the replication process?arrow_forwardAt very low pH, alanine is a diprotic acid that can be represented as H3N1-CH(CH3)-COOH. The pKa of the carboxyl group is 2.3, and the pKa of the UNH1 3 group is 9.7.(a) At pH 7, what fraction of the amino acid molecules dissolved in an aqueous solution will have the form H3N1-CH(CH3)-COO2?(b) What fraction of the molecules at this pH will havethe form H2N-CH(CH3)-COOH?arrow_forwardAnswer the (b) part of the question 6 (a) A decapeptide has the following amino acid composition: Ala2 , Arg, Cys, Glu, Gly, Leu, Lys, Phe, Val Partial hydrolysis yields the following tripeptides: Cys-Glu-Leu + Gly-Arg-Cys + Leu-Ala-Ala+ Lys-Val-Phe + Val-Phe-Gly. Reaction of the decapeptide with 2,4-dinitrofluorobenzene yields 2,4-dinitrophenylysine. From the experimental data, deduce the primary structure of the decapeptide. (b) Suggest a scheme you will follow to synthesize the dipeptide Ala-Glyarrow_forward
- Define the following terms :(i) Nucleotide(ii) Anomers(iii) Essential amino acidsarrow_forwardthe most prominent secondary structure element in silk fibroin is (a) beta sheet (b) e-amino group (c) alpha helix (d) antiparallel double helix (e) alphlamdapi n alpha helical coilarrow_forwardProvide the amino acid sequence for human insulin in the box provided (copy and paste the amino acid from the bottom of the NCBI page for AAH05255.1; leave the numbers 1 and 61 and do NOT eliminate spaces). 1 malwarrow_forward
- What is the structure, origin and catalytic role of Nicotinamide nucleotides?arrow_forwardPlease don't provide handwritten solution ....arrow_forwardDraw the structure of leu-enkephalin, a pentapeptide that acts as an analgesic and opiate, and has the following sequence: Tyr–Gly–Gly–Phe–Leu. (The structure of a related peptide, met-enkephalin, appeared in Section 22.6B.)arrow_forward
- Match the region A,B,Carrow_forward2. (a) Describe any two of the secondary structure elements found in peptides. (b) Why do Glycine and Proline destabilise an a-helix secondary structure element? (c) Provide a definition of the term isoelectric point? (d) Using the information given below, calculate the pl of the amino acid citrulline. H₂N pK₂ = 9.23 H₂N. NH COOH pK₂ = 2.27arrow_forward(a) Draw a structural formula for the products formed when alanine is treated with the following reagents. (i) (Boc)20, NaOH (ii) CbzCI, NazCO3 (iii) 2-Methylpropene, p-TSOH (b) Enfuvirtide, a 36-amino-acid peptide drug, was manufactured at a multi-tonne per year scale. The manufacture relied on solid phase synthesis with Barlos resin as the solid support. Part of the solid phase synthesis is shown below. Write the structure of the product A and discuss the cleavage mechaniśm of the peptide from the resin. 1. Fmoc-Leu-OH, DIPEA 2. 20% piperidine in DMF 3. Fmoc-Glu('Bu)-OH, HBTU, HOBt 4. 20% piperidine in DMF 5. Fmoc-Leu-OH, HBTU, HOBT 6. 20% piperidine in DMF 7. Fmoc-Leu-OH, HBTU, HOBE 8. 20% piperidine in DMF 9. 10% HOAC in CH2CI2 Barlos resinarrow_forward
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