Organic Chemistry (8th Edition)
Organic Chemistry (8th Edition)
8th Edition
ISBN: 9780134042282
Author: Paula Yurkanis Bruice
Publisher: PEARSON
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Chapter 25.8, Problem 16P
Interpretation Introduction

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Reason for two equivalent of NADPH is used to reduce hydroxymethylglutary-CoA to mevalonic acid has to be explained.

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Why are two equivalents of NADPH required to reduce hydroxymethylglutaryl-CoA to mevalonic acid?
Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbons is metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acid cycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitamins are the coenzymes derived?
Most fatty acids have an even number of carbons and, therefore, are completely metabolized to acetyl-CoA. A fatty acid with an odd number of carbons is metabolized to acetyl-CoA and one equivalent of propionyl-CoA. The following two reactions convert propionyl-CoA into succinyl-CoA, a citric acid cycle intermediate, so it can be further metabolized. Each of the reactions requires a coenzyme. Identify the coenzyme for each step. From what vitamins are the coenzymes derived?

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Organic Chemistry (8th Edition)

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