Microbiology with Diseases by Body System (4th Edition)
4th Edition
ISBN: 9780321918550
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 25, Problem 2MTF
Summary Introduction
Concept introduction:
Fermentation is an anaerobic process, in which simpler substances are formed from the breakdown of complex substance by the action of microbes, such as yeast or bacteria. Fermentation process is used for the production of wine, beer, yoghurt, bread, and some other food products.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 25 Solutions
Microbiology with Diseases by Body System (4th Edition)
Ch. 25 - Prob. 1TMWCh. 25 - Prob. 2TMWCh. 25 - Prob. 1MCCh. 25 - Prob. 2MCCh. 25 - Prob. 3MCCh. 25 - Prob. 4MCCh. 25 - Prob. 5MCCh. 25 - Strains of the bacterium Pseudomonas syringae have...Ch. 25 - Prob. 7MCCh. 25 - Prob. 8MC
Ch. 25 - Prob. 9MCCh. 25 - Prob. 19MCCh. 25 - Lyophilization in food preservation is by...Ch. 25 - Prob. 1MTFCh. 25 - Prob. 2MTFCh. 25 - Prob. 3MTFCh. 25 - Prob. 4MTFCh. 25 - Prob. 5MTFCh. 25 - Intrinsic factors affecting food spoilage are...Ch. 25 - Prob. 2FIBCh. 25 - Prob. 3FIBCh. 25 - Potable water is allowed to have ________...Ch. 25 - A ________ is a device composed of microbes and...Ch. 25 - Prob. 10FIBCh. 25 - Prob. 1MCh. 25 - Why does the application or recombinant DNA...Ch. 25 - Given what you know about microbial nutrition and...Ch. 25 - Prob. 3CTCh. 25 - Prob. 4CTCh. 25 - Even though water and wastewater undergo...Ch. 25 - Take a critical look at the garbage in all of your...Ch. 25 - Prob. 7CTCh. 25 - Explain why sakesometimes called rice winewould be...Ch. 25 - Prob. 10CTCh. 25 - Prob. 11CTCh. 25 - Suggest why neither the original food involved nor...Ch. 25 - Prob. 13CTCh. 25 - Prob. 14CTCh. 25 - Prob. 1CMCh. 25 - A blogger stated that germs (microorganisms) are...Ch. 25 - Compare human, animal, and plant pathogens that...Ch. 25 - A microbiome is composed of _____. a. single, pure...Ch. 25 - In the environment, nutrients are generally _____....Ch. 25 - Prob. 12MCCh. 25 - Prob. 13MCCh. 25 - Nitrification converts _____. a. organic nitrogen...Ch. 25 - Prob. 15MCCh. 25 - Which of the following diseases is not caused by...Ch. 25 - Of the following characteristics, which would...Ch. 25 - Anammox reactions are ____. a. anaerobic and pan...Ch. 25 - Prob. 6MTFCh. 25 - Modified True/False 1. _____ Biofilms of...Ch. 25 - Prob. 8MTFCh. 25 - Modified True/False 3. __________ Aquatic...Ch. 25 - Prob. 10MTFCh. 25 - Fill in the Blanks 1. Leaching of compounds from...Ch. 25 - Prob. 6FIBCh. 25 - Prob. 7FIBCh. 25 - Prob. 8FIBCh. 25 - Prob. 1VICh. 25 - Prob. 2VICh. 25 - Prob. 8CTCh. 25 - Microbes are found mostly in topsoil, but some are...
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