Concept explainers
(a)
Interpretation:
The step (of steps 1 through 4) and turn (second or third) of the β-oxidation pathway in which the following compound is encountered as a reactant if the degraded fatty acid is decanoic acid has to be determined.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
The functional group change in the β-oxidation pathway is as follows:
Here, R and R’ represent an alkyl group. In
(b)
Interpretation:
The step (of steps 1 through 4) and turn (second or third) of the β-oxidation pathway in which the following compound is encountered as a reactant if the degraded fatty acid is decanoic acid has to be determined.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
The functional group change in the β-oxidation pathway is as follows:
Functional groups are defined as the group of atoms which are attached to the carbon backbone of organic compounds. These are generally heteroatoms which are attached to the parent hydrocarbon chain. Some examples of functional groups are as follows:
Here, R and R’ represent an alkyl group. In alkene, R1, R2, R3, and R4 can be the same or different or can be hydrogen.
Alkanes are saturated hydrocarbons that contain covalently bonded hydrogen and carbon atoms. In secondary alcohol, the carbon atom of the hydroxyl group
(c)
Interpretation:
The step (of steps 1 through 4) and turn (second or third) of the β-oxidation pathway in which the following compound is encountered as a reactant if the degraded fatty acid is decanoic acid has to be determined.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
The functional group change in the β-oxidation pathway is as follows:
Functional groups are defined as the group of atoms which are attached to the carbon backbone of organic compounds. These are generally heteroatoms which are attached to the parent hydrocarbon chain. Some examples of functional groups are as follows:
Here, R and R’ represent an alkyl group. In alkene, R1, R2, R3, and R4 can be the same or different or can be hydrogen.
Alkanes are saturated hydrocarbons that contain covalently bonded hydrogen and carbon atoms. In secondary alcohol, the carbon atom of the hydroxyl group
(d)
Interpretation:
The step (of steps 1 through 4) and turn (second or third) of the β-oxidation pathway in which the following compound is encountered as a reactant if the degraded fatty acid is decanoic acid has to be determined.
Concept introduction:
The β-oxidation pathway is defined as a repetitive series of four biochemical reactions in which acyl CoA is degraded to acetyl CoA by the removal of two carbon atoms at a time. NADH and FADH2 are also produced in this pathway.
The functional group change in the β-oxidation pathway is as follows:
Functional groups are defined as the group of atoms which are attached to the carbon backbone of organic compounds. These are generally heteroatoms which are attached to the parent hydrocarbon chain. Some examples of functional groups are as follows:
Here, R and R’ represent an alkyl group. In alkene, R1, R2, R3, and R4 can be the same or different or can be hydrogen.
Alkanes are saturated hydrocarbons that contain covalently bonded hydrogen and carbon atoms. In secondary alcohol, the carbon atom of the hydroxyl group
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GENERAL,ORGANIC,+BIO.CHEM.-MINDTAP
- We have encountered reactions similar to the oxidation, hydration, and oxidation reactions of fatty acid degradation earlier in our study of biochemistry. What other pathway employs this set of reactions?arrow_forwardDefine beta-oxidation of fatty acids? Describe in detail three different steps of beta-oxidation of FAs.arrow_forwardCompare and contrast the pathway by which fatty acids are degraded (B-oxidation) with the pathway by which fatty acids are synthesized from acetyl-CoA. Comment on the following: (i) nature of the "activated" structures (ii) coenzymes involved (iii) stereochemistry of the intermediates (iv) sites where pathways occurarrow_forward
- Consider the fatty acids: (a) Arachidic acid (C20H40O2); molar mass = 312.5 g/mol) (b) Palmitoleic acid(C16H30O2); molar mass = 256.4 g/mol). i. How many cycles of β -oxidation are needed for complete oxidation?ii. How many molecules of acetyl CoA are formed from its complete catabolism?iii. Calculate the number of molecules (moles) of ATP formed (net) by the completecatabolism of each fatty acid (show your calculation).iv. Calculate number of moles of ATP formed per gram of each fatty acid metabolized.arrow_forwardAre any of the intermediates in the β-oxidation pathway chiral? Explain.arrow_forwarda. Arachidic acid is shown in the diagram below. How many rounds of β-oxidation will be needed to fully catabolize arachidic acid? b. What products will be obtained from the complete β-oxidation of arachidic acid? c. What will be the final ATP output (after TCA cycle and oxidative phosphorylation) obtained from the complete β-oxidation of arachidic acid?arrow_forward
- Triglyceride is an important energy reserve material for human body. When sugar supply is insufficient, triglyceride can be powered by B oxidation and decomposition of fatty acids. When sugar intake is excessive, triglyceride can also be synthesized by de novo synthesis. List the differences between the fatty acid beta oxidation pathway and the de novo synthesis pathway (identify at least five differences)arrow_forwardTransamination is an extremely important reaction in amino acid metabolism. Show, using mechanisms, how this is carried out in the 1st stage in which the products are an alpha-keto acid and an enzyme-bound coenzyme. Use alanine as your substrate. Include in your mechanism, the types of catalysis found.arrow_forwardPart A Identify each of the following metabolic pathways. Drag the appropriate labels to their respective targets. Reset Help the conversion of fatty acids to 2-carbon units of acetyl CoA ketogenesis the conversion of an amino acid to an a-keto transamination acid the combination of 2-carbon units of acetyl COA to form fatty acids oxidative deamination the removal of an amino group as NH4+ from B oxidation glutamate to yield a-ketoglutarate lipogenesis the production of ketone bodiesarrow_forward
- Describe how a) Mean Arterial Pressure, b) Maximal Oxygen Consumption, and c) Blood Flow are determined using its formula. In addition, you should explain what those factors are including cardiac output, stroke volume, heart rate, resistance, a-vO2 difference, etc. Describe how many ATPs can be generated by complete cycles of beta oxidation of free fatty acid with 20 carbons. You should indicate how many cycles of beta oxidation and Krebs cycle, and total number of products as wellarrow_forwardDefine the following terms: a. thiolytic cleavage b. ketogenesis c. ketone bodies d. α-oxidation e. ACCarrow_forwardYears ago there was interest in using uncouplers such as dinitrophenol asweight control agents. Presumably, fat could be oxidized without concomitant ATP synthesis for re-formation of fat or carbohydrate. Why was this a bad (i.e., fatal) idea?arrow_forward
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning