Chapter 25, Problem 25.17P

Interpretation Introduction

(a)

Interpretation:

A free-energy diagram showing ${\text{ΔG}}^{\text{o'}}$ for the biosynthesis of acetylcholine from acetyl-CoA and choline from the ${\text{ΔG}}^{\text{o'}}$ for hydrolysis of acetyl-CoA and choline is to be drawn.

Concept Introduction:

A large positive value of ${\text{ΔG}}^{\text{o'}}$ for a particular reaction shows that it is highly unfavorable reaction. The free energy change of two reactions can be used to determine the free energy change of a third reaction.

Interpretation Introduction

(b)

Interpretation:

${\text{ΔG}}^{\text{o'}}$ for the given biosynthetic reaction is to be calculated.

Concept Introduction:

The energy change for any reaction can be calculated as the sum of the energy changes for other reactions. These reactions can be treated just like algebraic equations.

Interpretation Introduction

(c)

Interpretation:

The equilibrium constant (${\text{K}}_{eq}$) for the given biosynthesis at $37℃$ is to be calculated

Concept Introduction:

The equilibrium constant (${\text{K}}_{eq}$) is to be calculated by using the formula:

${\text{ΔG}}^{\text{o'}}\text{=-2}{\text{.3RTlogK}}_{eq}$.

Using the value of the ${\text{ΔG}}^{\text{o'}}$, the value of ${\text{K}}_{eq}$ can be calculated.