Chapter 25, Problem 25.38AP

Interpretation Introduction

Interpretation:

It is to be explained how the $∆G^0$ for the hydrolysis of acetyl-CoA would change if the hydrolysis were carried out at $\mathrm{p}\mathrm{H}=11$

Concept Introduction:

At $\mathrm{p}\mathrm{H}=7$, hydrolysis can proceed with water. But, water is not a very good nucleophile. At $\mathrm{p}\mathrm{H}=11$, the reaction medium is basic. Hydroxide ion is present, which is a reactive nucleophile as compared to water.