The article “Doctor Dogs Diagnose Cancer by Sniffing It Out” (Knight Ridder Newspapers, January 9, 2006) reports the results of an experiment described in the journal Integrative Cancer Therapies. In this experiment, dogs were trained to distinguish between people with breast and lung cancer and people without cancer by sniffing exhaled breath. Dogs were trained to lie down if they detected cancer in a breath sample. After training, dogs’ ability to detect cancer was tested using breath samples from people whose breath had not been used in training the dogs. The paper states “The researchers blinded both the dog handlers and the experimental observers to the identity of the breath samples.” Explain why this blinding is an important aspect of the design of this experiment.
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- A researcher is studying the effects of his newly created lens on vision. He samples 9 people with poor vision and measures their visual distance (in feet) with the lens and then without the lens. Did people’s vision with the lens differ from their vision without? Participant # With Lens Without Lens 1 8 14 2 6 17 3 9 12 4 7 11 5 5 12 6 9 18 7 8 13 8 9 7 9 7 13 What kind of analysis will you use? Why? State the null and alternative hypothesis. Check your assumptions. Explain why each of them are or are not met. Sketch a distribution and shade the rejection region(s), including the corresponding critical value(s). Using R, calculate your test statistic and interpret the results of your test. (Don’t forget your 95% confidence interval and screenshots of your work!) What do you conclude about the null hypothesis? Are there significant differences?arrow_forwardThe authors of the paper "Statistical Methods for Assessing Agreement Between Two Methods of Clinical Measurement" compared two different instruments for measuring a subject's ability to breathe out air.+ (This measurement is helpful in diagnosing various lung disorders.) The two instruments considered were a Wright peak flow meter and a mini-Wright peak flow meter. Seventeen subjects participated in the study, and for each subject air flow was measured once using the Wright meter and once using the mini-Wright meter. Mini- Subject Wright Meter 1 2 3 4 5 6 7 8 9 512 430 520 428 500 600 364 380 658 Wright Meter 494 395 516 434 476 557 413 442 650 Subject 10 11 12 13 14 15 16 17 Mini- Wright Meter 445 432 626 260 477 259 350 451 Wright Meter 433 417 656 267 478 178 423 427 (a) Suppose that the Wright meter is considered to provide a better measure of air flow, but the mini-Wright meter is easier to transport and to use. If the two types of meters produce different readings but there is a…arrow_forwardA researcher conducts an independent-measures study to examine how the brain chemical serotonin is related to aggression. One sample of rats serves as a control group and receives a placebo that does not affect normal levels of serotonin. A second sample of rats, low serotonin group, receives a drug that lowers brain levels of serotonin. Then, the researcher tests the animals by recording the number of aggressive responses each of the rats display. See the data below. Is there a significant difference between the control group and the low serotonin group regarding the number of aggressive responses? Control Low Serotonin n = 10 n = 15 M = 14 M = 19 SS = 180.5 SS = 130 Perform a hypothesis test using independent-measures t-test. Use a two-tailed…arrow_forward
- A researcher conducts an independent-measures study to examine how the brain chemical serotonin is related to aggression. One sample of rats serves as a control group and receives a placebo that does not affect normal levels of serotonin. A second sample of rats, low serotonin group, receives a drug that lowers brain levels of serotonin. Then, the researcher tests the animals by recording the number of aggressive responses each of the rats display. See the data below. Is there a significant difference between the control group and the low serotonin group regarding the number of aggressive responses? Control Low Serotonin n = 10 n = 15 M = 14 M = 19 SS = 180.5 SS = 130 Perform a hypothesis test using independent-measures t-test. Use a two-tailed…arrow_forwardA researcher conducts an independent-measures study to examine how the brain chemical serotonin is related to aggression. One sample of rats serves as a control group and receives a placebo that does not affect normal levels of serotonin. A second sample of rats, low serotonin group, receives a drug that lowers brain levels of serotonin. Then, the researcher tests the animals by recording the number of aggressive responses each of the rats display. See the data below. Is there a significant difference between the control group and the low serotonin group regarding the number of aggressive responses? Control Low Serotonin n = 10 n = 15 M = 14 M = 19 SS = 180.5 SS = 130 Perform a hypothesis test using independent-measures t-test. Use a two-tailed…arrow_forwardMammography and clinical breast examination are the two major techniques used to screen for breast cancer. However, as true for any screening test, they are not completely accurate. If it is determined, based on mammographic findings, that there is a possibility of breast cancer, this is usually confirmed or disconfirmed by a subsequent biopsy. A false positive test is a mammogram positive test that is disconfirmed by biopsy. The data in Table 1 were reported in a paper concerning breast cancer screening (Elmore, et al, New England Journal of Medicine 1998; 338(16): 1089-1096). Table 1 False positive breast cancer screening tests over a 10-year period # Screening tests # False positive tests 9762 631 1. Another aspect of mammographic screening is the presence of false negatives. A false negative is a screen negative woman who has breast cancer. False negatives usually occur because the tumors are small and hard to detect. It is estimated that among women with breast cancer, 2% of all…arrow_forward
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