Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 22, Problem 23P
Cystic fibrosis (CF) is the most common autosomal recessive disorder in certain Caucasian populations. In some populations, approximately
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Students have asked these similar questions
Two parents, without any family history of cystic fibrosis (CF), have a child with CF.
A. What do you predict the genotypes of the parents to be? (CF is a recessive disorder.)
B. What is the chance that the next child of these two parents will also have CF?
Cystic Fibrosis (CF) is an autosomal recessive condition. Therefore, heterozygous (Cc) carriers do not display symptoms. Two parents who are carriers plan to start a family and you are a genetic counselor helping to advise them about their chances of having children affected by CF.
a) Suppose the couple has 4 children, each one year apart. What is the probability that all 4 children will inherit CF?
b) What is the probability that any 3 of their 4 children will not inherit CF, but 1 will be affected?
c) What is the probability that their first child will not inherit CF, but the younger 3 children will inherit CF?
BACKGROUND
Sickle cell disease is caused by a change in the gene for hemoglobin, which is the
oxygen-carrying protein in red blood cells. Individuals who are homozygous for
the sickle cell trait often cannot endure exercise. Individuals who are heterozygous
for the trait can have sickle cell attacks under extreme conditions. Normal
individuals (Hb Hb) have only normal hemoglobin. Homozygous sickle cell
individuals (Hb Hb') have only sickle cell hemoglobin. Heterozygous individuals
(Hbs Hb) have both normal hemoglobin and sickle cell hemoglobin.
Jerry Smith collapsed while running a race for his track team. A doctor said that
he had a sickle cell attack. Genetic tests were run on several family members. The
test results are shown below. An X indicates that form of hemoglobin in red blood
cells.
PROBLEM
How can you determine the genotypes of people in a family?
TABLE 1. FAMILY PHENOTYPES
Normal Hemoglobin
Subject
Jerry Smith
Jerry's brother
Jerry's younger sister
Jerry's youngest sister…
Chapter 22 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 22 - 20.1 Compare and contrast the terms in each of the...Ch. 22 - In a population, what is the consequence of...Ch. 22 - 20.3 Identify and describe the evolutionary forces...Ch. 22 - Describe how natural selection can produce...Ch. 22 - Thinking creatively about evolutionary mechanisms,...Ch. 22 - 20.6 Genetic drift, an evolutionary process...Ch. 22 - Over the course of many generations in a small...Ch. 22 - Catastrophic events such as loss of habitat,...Ch. 22 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 22 - 20.10 The ability to taste the bitter compound...
Ch. 22 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 22 - 20.12 Biologists have proposed that the use of...Ch. 22 - 20.13 Two populations of deer, one of them large...Ch. 22 - 20.14 Directional selection presents an apparent...Ch. 22 - 20.15 What is inbreeding depression? Why is...Ch. 22 - 20.16 Certain animal species, such as the...Ch. 22 - Genetic Analysis 20.1 predicts the number of...Ch. 22 - 20.18 In a population of rabbits, and . The...Ch. 22 - Sickle cell disease (SCD) is found in numerous...Ch. 22 - 20.20 Epidemiologic data on the population in the...Ch. 22 - The frequency of tasters and nontasters of PTC...Ch. 22 - Tay-Sachs disease is an autosomal recessive...Ch. 22 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 22 - 20.24 In the mouse, Mus musculus, survival in...Ch. 22 - 20.25 In a population of flowers growing in a...Ch. 22 - Assume that the flower population described in the...Ch. 22 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 22 - 20.28 A total ofmembers of a Central American...Ch. 22 - 20.29 A sample offield mice contains individuals...Ch. 22 - Prob. 30PCh. 22 - Albinism, an autosomal recessive trait...Ch. 22 - Prob. 32PCh. 22 - 20.33 Evaluate the following pedigree, and answer...Ch. 22 - Evaluate the following pedigree, and answer the...Ch. 22 - The following is a partial pedigree of the British...Ch. 22 - Draw a separate hypothetical pedigree identifying...Ch. 22 - Prob. 37PCh. 22 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 22 - 20.39 New allopolyploid plant species can arise by...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- A recessive disease is represented in 8% of the US population. What is the frequency of homozygous dominant, heterozygous and homozygous recessive individuals in the US population for that disease Homozygous dominant: 0.36 Heterozygous: 2 x 0.36 x 0.64 Homozygous recessive: 0.64 Homozygous dominant: 0.362 Heterozygous: 2 x 0.36 x 0.64 Homozygous recessive: 0.642 Homozygous dominant: 0.72 Heterozygous: 2 x 0.72 x 0.28 Homozygous recessive: 0.28 Homozygous dominant: 0.722 Heterozygous: 2 x 0.72 x 0.28 Homozygous recessive: 0.282arrow_forwardCystic fibrosis is an autosomal recessive disorder that affects 1 in 3 000 newborns with Caucasian background. It causes thick mucus build up in various organs and can cause damages and problems in respiratory and digestive systems. a) What is the frequency of the cystic fibrosis allele in the Caucasian population? Show all your work and express your answer as a value between 0 and 1 rounded to two decimal places. b) What percentage of the Caucasian population would be carriers for cystic fibrosis? Show all your work and express your answer rounded to two decimal places. c)If two individuals are carriers of the cystic fibrosis allele, what is the probability that they would have a girl without cystic fibrosis? Show all your work (including the Punnett square) and express your answer as a value between 0 and 1 rounded to two decimal places.arrow_forwardBelow in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. What type of genetic transmission is most consistent with the pedigree? Label all the individuals that you can determine, with hypothesized genotypes. Label the individuals that have unknown genotypes with possible genotypes. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.arrow_forward
- Below in Figure 1 is a pedigree for a family afflicted by a genetic disorder. In some populations, Cystic fibrosis has an incidence of 1 in 2500 newborns. The carrier frequency calculated from this is 1/25. Analyze the pedigree below assuming the disease is similar to cystic fibrosis in incidence and carrier frequency. However this disease may not have the same type of genetic transmission as cystic fibrosis. What type of genetic transmission is most consistent with the pedigree? Label all the individuals that you can determine, with hypothesized genotypes. Label the individuals that have unknown genotypes with possible genotypes. Assuming her father is known to NOT be a carrier, calculate the probability that IV1 is a carrier for disease. Use the Χ2 test to determine whether your proposed transmission fits this data.arrow_forwardPlease solvearrow_forwardIn Sweden 1/500 are born with an autosomal recessive disorder called thalassemia. What is the carrier frequency within the population?arrow_forward
- Cystic fibrosis is an autosomal recessive disease characterized by two copies of a mutated CFTR gene. If one in 100 (hypothetical scenario, not reality) people in the United States have cystic fibrosis, calculate the p and q frequency for the normal allele (p) and the mutated allele (q). Based on those calculations, what percentage of individuals would be expected to be homozygous dominant?arrow_forwardThe most common CF mutation is AF508; it accounts for approximately 70% of all mutant CFTR alleles worldwide. For a couple of northern European origin, what is their risk for having an affected child if each tests negative for AF508? If one tests positive and the other tests negative for AF508?arrow_forwardWhy Recessive CF disease alleles either produce no CFTR or produce nonfunctional or less functional versions of the protein?arrow_forward
- The allele for sickle anemia is found at higher frequencies in central Africa than in other parts of the world. What are the advantage and disadvantages?arrow_forwardIf the frequency of the aa genotype is 19%, what is the frequency of the AA genotype? Assume that there are only two alleles (i.e. a and A).arrow_forwardIn humans, people with at least one dominant RhD allele have a Rh positive blood type. People with a homozygous recessive genotype have a Rh negative blood type. In the United States, 85% of the population is Rh positive and 15% are Rh negative. What are the values of p and q for the population in the United States (assuming that the American population is at Hardy-Weinberg equilibrium)?arrow_forward
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