Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 22, Problem 35P
The following is a partial pedigree of the British royal family. The family contains several inbred individuals and a number of inbreeding pathways. Carefully evaluate the pedigree, and identify the pathways and common ancestors that produce inbred individuals A (Alice in generation IV), B (George VI in generation VI), and C (Charles in generation VIII).
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A family tree of sorts is called a pedigree. The symbols used for a pedigree are:
female, unaffected
female, affected
☐male, unaffected
male, affected
I
11
III
1
Pedigree Chart
Minor Peta #2
Siblings are placed in hirth order from left to right and are
labeled with Arabic numerals. Each generation is labeled
with a Roman numeral. Therefore, the male exhibiting the
trait in the pedigree below in the bottom, center would be
identified as III-4.
1. Which members of the family above are affected by Huntington's Disease?
4. How many girls did II-1 and 11-2 have?
3. How many children did individuals 1-1 and 1-2 have?
2. There are no carriers for Huntington's Disease- you either have it or you don't. With this in mind, is Huntington's disease
caused by a dominant or recessive trait?
5. How are individuals III-2 and II-4 related?
8
-Huntington's
Disease
The pedigree shown below depicts crosses performed as part of an antelope captive-breeding program. Use the pedigree information to calculate the coefficient of inbreeding (F) for the mating of IV-12 and III-9 that produces the animal identified as V-13.
Chapter 22 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 22 - 20.1 Compare and contrast the terms in each of the...Ch. 22 - In a population, what is the consequence of...Ch. 22 - 20.3 Identify and describe the evolutionary forces...Ch. 22 - Describe how natural selection can produce...Ch. 22 - Thinking creatively about evolutionary mechanisms,...Ch. 22 - 20.6 Genetic drift, an evolutionary process...Ch. 22 - Over the course of many generations in a small...Ch. 22 - Catastrophic events such as loss of habitat,...Ch. 22 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 22 - 20.10 The ability to taste the bitter compound...
Ch. 22 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 22 - 20.12 Biologists have proposed that the use of...Ch. 22 - 20.13 Two populations of deer, one of them large...Ch. 22 - 20.14 Directional selection presents an apparent...Ch. 22 - 20.15 What is inbreeding depression? Why is...Ch. 22 - 20.16 Certain animal species, such as the...Ch. 22 - Genetic Analysis 20.1 predicts the number of...Ch. 22 - 20.18 In a population of rabbits, and . The...Ch. 22 - Sickle cell disease (SCD) is found in numerous...Ch. 22 - 20.20 Epidemiologic data on the population in the...Ch. 22 - The frequency of tasters and nontasters of PTC...Ch. 22 - Tay-Sachs disease is an autosomal recessive...Ch. 22 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 22 - 20.24 In the mouse, Mus musculus, survival in...Ch. 22 - 20.25 In a population of flowers growing in a...Ch. 22 - Assume that the flower population described in the...Ch. 22 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 22 - 20.28 A total ofmembers of a Central American...Ch. 22 - 20.29 A sample offield mice contains individuals...Ch. 22 - Prob. 30PCh. 22 - Albinism, an autosomal recessive trait...Ch. 22 - Prob. 32PCh. 22 - 20.33 Evaluate the following pedigree, and answer...Ch. 22 - Evaluate the following pedigree, and answer the...Ch. 22 - The following is a partial pedigree of the British...Ch. 22 - Draw a separate hypothetical pedigree identifying...Ch. 22 - Prob. 37PCh. 22 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 22 - 20.39 New allopolyploid plant species can arise by...
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- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forward
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- A family pedigree is shown here. A. What is the inbreeding coefficient for individual IV-2? Who is/ are her parents’ common ancestor(s)? B. Based on the data shown in this pedigree, is individual III-4 inbredarrow_forwardProfessor John decided to breed bunnies during stay-at-home because why not. She performed the following cross:Parents:brown fur, gray nose x white fur, gray noseOffspring:3/8 white fur, gray nose1/8 white fur, white nose3/8 brown fur, gray nose 1/8 brown fur, white noseBased on the phenotypes of the offspring, what are the genotypes of the parents? Make sure you define your genotypes (ie B is brown fur, b is white fur)arrow_forwardFrom the pedigree shown here, answer the following questions with regard to individual VII-1. A. Who are the common ancestors of her parents? B. What is the inbreeding coefficient for this individual?arrow_forward
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