Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 22, Problem 35P
The following is a partial pedigree of the British royal family. The family contains several inbred individuals and a number of inbreeding pathways. Carefully evaluate the pedigree, and identify the pathways and common ancestors that produce inbred individuals A (Alice in generation IV), B (George VI in generation VI), and C (Charles in generation VIII).
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
both images go together for the question
A family tree of sorts is called a pedigree. The symbols used for a pedigree are:
female, unaffected
female, affected
☐male, unaffected
male, affected
I
11
III
1
Pedigree Chart
Minor Peta #2
Siblings are placed in hirth order from left to right and are
labeled with Arabic numerals. Each generation is labeled
with a Roman numeral. Therefore, the male exhibiting the
trait in the pedigree below in the bottom, center would be
identified as III-4.
1. Which members of the family above are affected by Huntington's Disease?
4. How many girls did II-1 and 11-2 have?
3. How many children did individuals 1-1 and 1-2 have?
2. There are no carriers for Huntington's Disease- you either have it or you don't. With this in mind, is Huntington's disease
caused by a dominant or recessive trait?
5. How are individuals III-2 and II-4 related?
8
-Huntington's
Disease
The pedigree shown below depicts crosses performed as part of an antelope captive-breeding program. Use the pedigree information to calculate the coefficient of inbreeding (F) for the mating of IV-12 and III-9 that produces the animal identified as V-13.
Chapter 22 Solutions
Genetic Analysis: An Integrated Approach (2nd Edition)
Ch. 22 - 20.1 Compare and contrast the terms in each of the...Ch. 22 - In a population, what is the consequence of...Ch. 22 - 20.3 Identify and describe the evolutionary forces...Ch. 22 - Describe how natural selection can produce...Ch. 22 - Thinking creatively about evolutionary mechanisms,...Ch. 22 - 20.6 Genetic drift, an evolutionary process...Ch. 22 - Over the course of many generations in a small...Ch. 22 - Catastrophic events such as loss of habitat,...Ch. 22 - 20.9 George Udny Yule was wrong in suggesting that...Ch. 22 - 20.10 The ability to taste the bitter compound...
Ch. 22 - Figure 20.6 illustrates the effect of an ethanol ...Ch. 22 - 20.12 Biologists have proposed that the use of...Ch. 22 - 20.13 Two populations of deer, one of them large...Ch. 22 - 20.14 Directional selection presents an apparent...Ch. 22 - 20.15 What is inbreeding depression? Why is...Ch. 22 - 20.16 Certain animal species, such as the...Ch. 22 - Genetic Analysis 20.1 predicts the number of...Ch. 22 - 20.18 In a population of rabbits, and . The...Ch. 22 - Sickle cell disease (SCD) is found in numerous...Ch. 22 - 20.20 Epidemiologic data on the population in the...Ch. 22 - The frequency of tasters and nontasters of PTC...Ch. 22 - Tay-Sachs disease is an autosomal recessive...Ch. 22 - 20.23 Cystic fibrosis (CF) is the most common...Ch. 22 - 20.24 In the mouse, Mus musculus, survival in...Ch. 22 - 20.25 In a population of flowers growing in a...Ch. 22 - Assume that the flower population described in the...Ch. 22 - 20.27 ABO blood type is examined in a Taiwanese...Ch. 22 - 20.28 A total ofmembers of a Central American...Ch. 22 - 20.29 A sample offield mice contains individuals...Ch. 22 - Prob. 30PCh. 22 - Albinism, an autosomal recessive trait...Ch. 22 - Prob. 32PCh. 22 - 20.33 Evaluate the following pedigree, and answer...Ch. 22 - Evaluate the following pedigree, and answer the...Ch. 22 - The following is a partial pedigree of the British...Ch. 22 - Draw a separate hypothetical pedigree identifying...Ch. 22 - Prob. 37PCh. 22 - 20.38 Achromatopsia is a rare autosomal recessive...Ch. 22 - 20.39 New allopolyploid plant species can arise by...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Pedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. If Sarah carries the mutant cancer allele and Adam carries the mutant heart disease allele, what is the chance that they would have a child who is free of both diseases? Are these good odds?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you want to know the results of the cancer, heart disease, and TSD tests if you were Sarah and Adam? Is it their responsibility as potential parents to gather this type of information before they decide to have a child?arrow_forwardPedigree analysis is a fundamental tool for investigating whether or not a trait is following a Mendelian pattern of inheritance. It can also be used to help identify individuals within a family who may be at risk for the trait. Adam and Sarah, a young couple of Eastern European Jewish ancestry, went to a genetic counselor because they were planning a family and wanted to know what their chances were for having a child with a genetic condition. The genetic counselor took a detailed family history from both of them and discovered several traits in their respective families. Sarahs maternal family history is suggestive of an autosomal dominant pattern of cancer predisposition to breast and ovarian cancer because of the young ages at which her mother and grandmother were diagnosed with their cancers. If a mutant allele that predisposed to breast and ovarian cancer was inherited in Sarahs family, she, her sister, and any of her own future children could be at risk for inheriting this mutation. The counselor told her that genetic testing is available that may help determine if this mutant allele is present in her family members. Adams paternal family history has a very strong pattern of early onset heart disease. An autosomal dominant condition known as familial hypercholesterolemia may be responsible for the large number of deaths from heart disease. As with hereditary breast and ovarian cancer, genetic testing is available to see if Adam carries the mutant allele. Testing will give the couple more information about the chances that their children could inherit this mutation. Adam had a first cousin who died from Tay-Sachs disease (TSD), a fatal autosomal recessive condition most commonly found in people of Eastern European Jewish descent. Because TSD is a recessively inherited disorder, both of his cousins parents must have been heterozygous carriers of the mutant allele. If that is the case, Adams father could be a carrier as well. If Adams father carries the mutant TSD allele, it is possible that Adam inherited this mutation. Because Sarah is also of Eastern European Jewish ancestry, she could also be a carrier of the gene, even though no one in her family has been affected with TSD. If Adam and Sarah are both carriers, each of their children would have a 25% chance of being afflicted with TSD. A simple blood test performed on both Sarah and Adam could determine whether they are carriers of this mutation. Would you decide to have a child if the test results said that you carry the mutation for breast and ovarian cancer? The heart disease mutation? The TSD mutation? The heart disease and the mutant alleles?arrow_forward
- Pedigree Analysis Is a Basic Method in Human Genetics Using the pedigree provided, answer the following questions. a. Is the proband male or female? b. Is the grandfather of the proband affected? c. How many siblings does the proband have, and where is he or she in the birth order?arrow_forwardIn cattle, coats may be solid white, solid black, or black-and-whitespotted. When true-breeding solid whites are mated with truebreeding solid blacks, the F1 generation consists of all solid white individuals. After many F1 * F1 matings, the following ratio was observed in the F2 generation: 12/16 solid white3/16 black-and-white spotted1/16 solid black Explain the mode of inheritance governing coat color by determining how many gene pairs are involved and which genotypes yield which phenotypes. Is it possible to isolate a true-breeding strain of black-and-white spotted cattle? If so, what genotype would they have? If not, explain why not.arrow_forwardA dark-red strain and a white strain of wheat are crossed andproduce an intermediate, medium-red F1. When the F1 plants areinterbred, an F2 generation is produced in a ratio of 1 dark-red:4 medium-dark-red: 6 medium-red: 4 light-red: 1 white. Furthercrosses reveal that the dark-red and white F2 plants are truebreeding. How many additive alleles are needed to produce each possiblephenotype?arrow_forward
- Each generation is represented by a Roman Numeral and each individual by a number. Based on the pedigree above, there are 2 generations. I-1 is the male parent and l-2 is the female parent. Generation Il are their children, with Il-1 as the eldest (daughter), Il-2 the middle child (son) and II-3 another daughter as the youngest. An arrow that points to any individual in the pedigree chart identifies the individual as a proband, an individual affected with a disorder (II-3 in the pedigree above) who is the first subject in a study (as of a genetic character in a family lineage) (Merriam-Webster.com). The proband can be specified in the problem. Answer the following using the spaces provided. 1. This pedigree tracks the inheritance of freckles, an autosomal dominant trait, for 3 generations. Determine the genotypes of all individual in the chart. 1-1 III-1 II-2 Il-1 1-2 Il-2 Il-3 Il-4 III-3 III-4 Il-5 III-5 III-6 If III-6 marries someone without freckles, is it possible for them to have…arrow_forwardA true-breeding purple-leafed plant isolated from one side of El Yunque, the rain forest in Puerto Rico, was crossed to a truebreeding white variety found on the other side. The F1 offspring were all purple. A large number of F1 * F1 crosses produced the following results: purple: 4219 white: 5781 (Total = 10,000) Propose an explanation for the inheritance of leaf color. As a geneticist, how might you go about testing your hypothesis? Describe the genetic experiments that you would conductarrow_forwardDihybrid and trihybrid Cross Get the genotypic and phenotypic ratio of the following: Dihybrid cross: Harry has 1 pair of dog, he's going to breed his Pure black, furry male to his white furless female (P generation). Also, he wants to find out what will be the result if he breed 2 offspring from F1 generation. Help him to predict the P and G ratio of F1 and F2 generation using the Punnett Square. Dominant Recessive Black White Furry Furless Trihybrid cross: Breed AaBbCc to another AaBbCc.arrow_forward
- A family pedigree is shown here. A. What is the inbreeding coefficient for individual IV-2? Who is/ are her parents’ common ancestor(s)? B. Based on the data shown in this pedigree, is individual III-4 inbredarrow_forwardProfessor John decided to breed bunnies during stay-at-home because why not. She performed the following cross:Parents:brown fur, gray nose x white fur, gray noseOffspring:3/8 white fur, gray nose1/8 white fur, white nose3/8 brown fur, gray nose 1/8 brown fur, white noseBased on the phenotypes of the offspring, what are the genotypes of the parents? Make sure you define your genotypes (ie B is brown fur, b is white fur)arrow_forwardFrom the pedigree shown here, answer the following questions with regard to individual VII-1. A. Who are the common ancestors of her parents? B. What is the inbreeding coefficient for this individual?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
How to solve genetics probability problems; Author: Shomu's Biology;https://www.youtube.com/watch?v=R0yjfb1ooUs;License: Standard YouTube License, CC-BY
Beyond Mendelian Genetics: Complex Patterns of Inheritance; Author: Professor Dave Explains;https://www.youtube.com/watch?v=-EmvmBuK-B8;License: Standard YouTube License, CC-BY