Concept explainers
(a)
Interpretation:
The product formed on Aldol condensation in the given reaction is to be stated.
Concept introduction:
In Aldol condensation reaction, the base abstracts an acidic proton from the
(b)
Interpretation:
The product formed on Aldol condensation in the given reaction is to be stated
Concept introduction:
In Aldol condensation reaction, the base abstracts an acidic proton from the
(c)
Interpretation:
The product formed on aldol condensation in the given reaction is to be stated.
Concept introduction:
In Aldol condensation reaction, the base abstracts an acidic proton from the
(d)
Interpretation:
The product formed on aldol condensation in the given reaction is to be stated.
Concept introduction:
In Aldol condensation reaction, the base abstracts an acidic proton from the
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Organic Chemistry Study Guide and Solutions
- For the following structure, (a) propose the starting materials necessary to form it through an aldol reaction. (b) Identify the carbonyl electrophile, and the site of deprotonation for generation of the nucleophile to be used in the forward reaction. (Writing out the forward synthesis is not necessary.)arrow_forwardExplain how benzaldehyde and dimedone reacts with each other, and then with the aminotriazole to form compound 1a in the presence of an acid catalyst. Provide a detailed reaction mechanism and explanation.arrow_forwardArrange each group of compounds in order of increasing basicity.(a) CH3COO-, ClCH2COO-, and PhO- (b) sodium acetylide, sodium amide, and sodium acetate(c) sodium benzoate, sodium ethoxide, and sodium phenoxide (d) pyridine, sodium ethoxide, and sodium acetatearrow_forward
- (a) What product is formed by the Claisen rearrangement of compound Z? (b) Using what you have learned about ring-closing metathesis in Chapter 26, draw the product formed when the product in part (a) is treated with Grubbs catalyst. These two reactions are key steps in the synthesis of garsubellin A, a biologically active natural product that stimulates the synthesis of the neurotransmitter acetylcholine. Compounds of this sort may prove to be useful drugs for the treatment of neurodegenerative diseases such as Alzheimer’s disease.arrow_forward(b) Give both the structures and IUPAC names of the reactants for the compound below formed via a crossed aldol reaction with KOH as promotor. Explain why only one product is formed:arrow_forward(a) What product is formed by the Claisen rearrangement of compound Z? (b) Using what you have learned about ring-closing metathesis in Chapter 24, draw the product formed when the product in part (a) is treated with Grubbs catalyst. These two reactions are key steps in the synthesis of garsubellin A, a biologically active natural product that stimulates the synthesis of the neurotransmitter acetylcholine. Compounds of this sort may prove to be useful drugs for the treatment of neurodegenerative diseases such as Alzheimer's disease.arrow_forward
- Provide the reagents and solvents (where appropriate) needed to bring about the following transformations. (a) CI (b)arrow_forwardGive answer all the question with explanationarrow_forward(a) Explain why an alkylamine is more basic than ammonia?(b) How would you convert(i) Aniline to nitrobenzene (ii) Aniline to iodobenzenearrow_forward
- The saccharide shown here is present in some plant-derived foods. (a) Indicate the anomeric carbon atom(s) in this structure by drawing a circle around the atom(s) or by drawing an arrow pointing to the atom(s). (b) Would this saccharide give a positive result with Benedict’s reagent? Why or why not? (c) Would this saccharide give a positive result with Barfoed’s reagent? Why or why not? (d) Would this saccharide give a positive result with Seliwanoff’s reagent? Why or why not? (e) In a separate set of experiments, the saccharide solution was treated with a reagent that breaks glycosidic bonds. After this treatment, would any of the three assays give different results? Be sure to indicate which assay results would be different and give a reason.arrow_forwardIdentify ALL of the nucleophiles in each of the following molecules. H. (a) (c) NH2 tu (b) Li (d) NaOHarrow_forward(a) p-Nitrobenzaldehyde is reactive toward nucleophilic additions than p- more methoxybenzaldehyde. Draw both of the molecular structures and explain the observation. (b) Cyclohexanone forms a cyanohydrin in good yield but 2,2,6-trimethylcyclohexanone does not. Draw both of the molecular structures and explain the observation.arrow_forward
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