Human Anatomy & Physiology
1st Edition
ISBN: 9780805382952
Author: Erin C. Amerman
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 19, Problem 3CYU
The anticoagulant drug warfarin primarily disrupts the extrinsic/tissue factor coagulation pathway. Explain why disrupting only this pathway disrupts the entire coagulation cascade.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Why is Partial thromboplastin used in monitoring warfarin therapy? Explain.
It is known that heparin acts by increasing the activity of antithrombin, causing a conformational change. LMWHs inhibit mainly factor Xa. Although low doses of heparin act primarily by neutralizing factor Xa, at high doses it prevents thrombin-induced platelet activation and prolongs bleeding time. What are major clinical benefits using heparin or LMWHs?
What specific adverse effect is a sickle cell patient at risk for due to blood transfusions, in addition to the typical transfusion reactions? Discuss factors and rationale that put this patient at risk.
Chapter 19 Solutions
Human Anatomy & Physiology
Ch. 19.1 - Prob. 1QCCh. 19.1 - Prob. 2QCCh. 19.1 - 3. How does blood regulate temperature and...Ch. 19.1 - 4. What are the four main categories of plasma...Ch. 19.1 - Prob. 5QCCh. 19.2 - Describe the structure of a typical erythrocyte.Ch. 19.2 - Prob. 2QCCh. 19.2 - 3. Walk through the basic steps of...Ch. 19.2 - 4. What is the lifespan of an erythrocyte?
Ch. 19.2 - Prob. 5QC
Ch. 19.2 - Prob. 6QCCh. 19.2 - Prob. 7QCCh. 19.3 - How do granulocytes and agranulocytes differ?Ch. 19.3 - Prob. 2QCCh. 19.3 - Compare the two types of agranulocytes.Ch. 19.3 - 4. How do B and T lymphocytes differ?
Ch. 19.3 - 5. What does a monocyte become in the tissues?...Ch. 19.3 - Prob. 6QCCh. 19.3 - 7. How do the lymphoid and myeloid cell lines...Ch. 19.3 - 8. Where do T and B lymphocytes mature?
Ch. 19.4 - Prob. 1QCCh. 19.4 - Prob. 2QCCh. 19.5 - Prob. 1QCCh. 19.5 - Prob. 2QCCh. 19.5 - 3. How are platelets triggered to aggregate?
Ch. 19.5 - Prob. 4QCCh. 19.5 - How do the intrinsic/contact activation and...Ch. 19.5 - Prob. 6QCCh. 19.5 - Prob. 7QCCh. 19.5 - What is thrombolysis?Ch. 19.5 - Prob. 9QCCh. 19.5 - Prob. 10QCCh. 19.5 - Prob. 11QCCh. 19.5 - Prob. 12QCCh. 19.5 - Prob. 13QCCh. 19.5 - Prob. 14QCCh. 19.6 - Prob. 1QCCh. 19.6 - Prob. 2QCCh. 19.6 - Prob. 3QCCh. 19.6 - Prob. 4QCCh. 19.6 - Prob. 5QCCh. 19 - Prob. 1CYRCh. 19 - Prob. 2CYRCh. 19 - List the seven major functions of blood.Ch. 19 - Prob. 4CYRCh. 19 - Prob. 5CYRCh. 19 - Prob. 6CYRCh. 19 - Prob. 7CYRCh. 19 - Leukocytes are: a. nucleated cells that function...Ch. 19 - Prob. 9CYRCh. 19 - Fill in the blanks: Lymphocytes are derived from...Ch. 19 - Prob. 11CYRCh. 19 - Number the steps of hemostasis in order, putting 1...Ch. 19 - Prob. 13CYRCh. 19 - Prob. 14CYRCh. 19 - Prob. 15CYRCh. 19 - Prob. 16CYRCh. 19 - Prob. 17CYRCh. 19 - 18. Which antigens does a person with blood type...Ch. 19 - Prob. 19CYRCh. 19 - Prob. 20CYRCh. 19 - 1. Explain how blood, being a liquid, enables all...Ch. 19 - Prob. 2CYUCh. 19 - 3. The anticoagulant drug warfarin primarily...Ch. 19 - 4. Cirrhosis of the liver often reduces production...Ch. 19 - 1. A blood sample from your patient shows that she...Ch. 19 - Prob. 2AYKACh. 19 - Prob. 3AYKACh. 19 - Prob. 4AYKB
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Heparin is an activator of antithrombin III. In addition to thrombin, which additional coagulation factors are targeted by the antithrombin IlI:heparin complex? Currently Selected : B A Factor X В Factor VII Factor VIII Factor Varrow_forwardWhy is it important for people with hemophilia not to useaspirin?arrow_forwardHyperglycemia associated with diabetes promotes a prothrombotic state by affecting a number of different steps in the clotting pathway. Which of the following would result in more rather than less clotting? Check all that apply. The correct answers reflect the effect of hyperglycemia on the clotting pathway! less conversion of plasminogen to plasmin 7 000000000 abnormally low number of platelets platelets more sensitive to thromboxane A2 elevated conversion of plasminogen to plasmin platelets less sensitive to thromboxane A2 low sensitivity to NO and PGI2 increased prothrombin in the blood increased amount of fibrinogen in the blood less prothrombin in the blood abnormally high number of platelets less fibrinogen in the blood high sensitivity to NO and PGI2arrow_forward
- Hemostasis is a quick and localized sequence (cascade) of events that helps to prevent a hemorrhage from occurring when a blood vessel is damaged. Hemostasis involves – amongst other things – the formation of a platelet plug. Describe the three steps involved in the formation of a platelet plug. What complication may arise if a platelet plug (thrombus) were to detach and travel through the circulatory system? How does Aspirin help prevent a thrombus from occurring?arrow_forwardBriefly Explain the mechanism of aspirin induced anti-platelet activity? explain at your own wordsarrow_forwardName the enzyme that catalyses the formation of carbonic acid in erythtocytes.arrow_forward
- Explain the difference in the initiating event between the intrinsic pathway and the extrinsic pathway for blood coagulation.arrow_forwardA patient with chronic-stable angina begins taking metoprolol, and once blood levels reach the therapeutic range the frequency and severity of angina attacks and the need for sublingual nitroglycerin were reduced. Which of the following states the direct pharmacologic action by which the beta-blocker produced the desired effects? Decreased myocardial oxygen demand Dilated coronary vasculature Directly inhibited angiotensin II synthesis Reduced total peripheral resistancearrow_forwardWhich of the following scenarios might occur when a patients neutrophils are defective for the production of reactive oxygen species or other oxidases? (A) The neutrophils cannot phagocytoses bacteria or fungi. (b) The neutrophils can phagocytoses bacteria or fungi, but cannot destroy then. (c) The neutrophils cannot undergo diapedesis.arrow_forward
- Describe the changes in clotting and bleeding balance during disseminated intravascular coagulation (DIC). Describe the most important blood coagulation tests used to monitor the patients receiving heparin and warfarin. Distinguish between immediate and delayed hypersensitivity. What drugs are used to treat immediate hypersensitivity and how do these drug work? Why don’t these compounds work in treating delayed hypersensitivity?arrow_forwardA patient has frequent episodes of paroxysmal atrial fibrillation. He has received a medication for prophylaxis of these events. Which of the following is the most suitable for long term use? Nifedipine Adenosine Amiodarone Heparin Lidocainearrow_forwardDiscuss the process of blood coagulation and clotting. What is the mechanism by which blood clots dissolve? Describe how antiplatelet agents, anticoagulants, low-molecular-weight heparins, thrombolytic agents, antihemophilic agents, and hemostatic agents aftert blood clottine.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY