EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 19, Problem 11P
Drosophila researchers have collected many strains that carry a single recombinant P element containing a wild-type white gene (a P[w+] transgene) inserted into a known genomic location. These strains can be used to map the location of any mutant gene in the fly genome.
Investigators performed a testcross to map a recessive mutation rough (ro), which causes rough eyes, relative to a P[w+] element on chromosome 3. Females heterozygous for the P[w+] on one chromosome 3 and a ro− mutation on the other, homologous chromosome 3 were crossed to ro−/ro− males, and the progeny in the following list were obtained. In both the parents and the progeny, the endogenous white gene is nonfunctional—the flies have red eyes only if they contain the P[w+] transgene.
| a. | Are ro and the P[w+] linked? If so, how many map units separate them? |
| b. | The data in part (a) do not indicate on which side of the P[w+] (toward the centromere or telomere) the ro gene is located. How could the experiment be modified to reveal that information? |
| c. | Suppose you map the ro mutation to a genomic region between two different P[w+] elements that are 5000 bp apart. Describe some experimental approaches that would allow you to identify the ro gene at the molecular level. |
| d. | How could you use the DNA sequence of the ro gene to determine the function of the protein it encodes? |
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Chapter 19 Solutions
EBK GENETICS: FROM GENES TO GENOMES
Ch. 19 - Match each of the terms in the left column to the...Ch. 19 - a. If you were interested in the role of a...Ch. 19 - Early C. elegans embryos display mosaic...Ch. 19 - Hypomorphic mutations in the wingless gene of...Ch. 19 - Prob. 5PCh. 19 - In 1932, H. J. Muller suggested a genetic test to...Ch. 19 - a. Explain how you could use worms transformed...Ch. 19 - Suppose you want to determine whether a particular...Ch. 19 - Sevenless is an unusual receptor protein in that...Ch. 19 - Suppose that you generated flies containing a...
Ch. 19 - Drosophila researchers have collected many strains...Ch. 19 - As an alternative to random mutagenesis,...Ch. 19 - A C. elegans nematode gene called par-1 helps to...Ch. 19 - The molecular identity of the fruit fly rugose...Ch. 19 - To determine the focus of action of boss,...Ch. 19 - Suppose a particular gene is required for early...Ch. 19 - Researchers have exploited Minute mutations in...Ch. 19 - Some ts alleles are temperature sensitive during...Ch. 19 - The following figure shows the temperature-shift...Ch. 19 - A temperature-sensitive allele of the gene...Ch. 19 - Hypomorphic alleles of a pleiotropic gene...Ch. 19 - In addition to the maternal effect genes that...Ch. 19 - The yan gene encodes a transcription factor that...Ch. 19 - Recall from Chapter 17 that in Drosophila, sex...Ch. 19 - a. Explain the difference between maternal...Ch. 19 - In the 1920s, Arthur Boycott, working with the...Ch. 19 - The Drosophila mutant screen shown on the...Ch. 19 - Some genes are required both zygotically and...Ch. 19 - How would a human with a mutation in a maternal...Ch. 19 - One important demonstration that Bicoid is an...Ch. 19 - The hunchback gene contains a 5 transcriptional...Ch. 19 - In flies developing from eggs laid by a...Ch. 19 - Wild-type embryos and mutant embryos lacking the...Ch. 19 - The Drosophila even-skipped eve gene has four...Ch. 19 - In Drosophila with loss-of-function mutations...Ch. 19 - It is crucial to the development of Drosophila...Ch. 19 - In the plant Arabidopsis thaliana, every flower is...
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