Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 28P

In C. elegans there are two sexes: hermaphrodite and male. Sex is determined by the ratio of X chromosomes to haploid sets of autosomes (X / A). An X / A ratio of 1.0 produces a hermaphrodite (XX), and an X / A ratio of 0.5 results in a male (XO). In the 1970 s , Jonathan Hodgkin and Sydney Brenner carried out genetic screens to identify mutations in three genes that result in either XX males ( tra-1 , tra-2 ) or XO hermaphrodites ( her-1 ). Double mutant strains were constructed to assess for epistatic interactions between the genes (see table). Propose a genetic model of how the her and tra genes control sex determination.

Chapter 18, Problem 28P, In C. elegans there are two sexes: hermaphrodite and male. Sex is determined by the ratio of X

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Genetic Analysis: An Integrated Approach (3rd Edition)

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