Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 18, Problem 18P
Summary Introduction

To analyze:

The bristles that are developed from the epidermis in Drosophila are equally spaced, that makes the two bristles never come about immediately adjacent to each other. Based on this information question is asked how this pattern is established during development.

Introduction:

The pattern of regularly spaced sensory organs is most often observed in many animals. Bristles are such sensory organs which are found on the notum of the Drosophila. These bristles are classified into two classes: the macrochaetes and the microchaetes. The macrochaetes are larger and constant a number of bristles. Each bristle develops from a single cell (precursor) that divides into four cells that construct the bristles organ.

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a) Do the loss of function phenotypes differ between the genes between the genes in figure 1? What does this mean? b) What are the two cell types responsible for producing maternal gene products involved in terminal patterning in the Drosophila cocyte? In which of these two cell types is each of the three genes expressed? c) Based on the phenotypes you observed for the three genes, and on the differences in their expression patterns, which one of the genes do you think is the localised determinant of terminal patterning? d❘ From the gain-of-function experiments, do trunk and torso like work upstream or downstream of torso? Explain. (4 m e) How might you test which of the trunk and torso-like genes acts upstream of the other? f) The torso gene has been shown to have another important role in Drosophila development outside of terminal patterning. What do you think would be a good first experiment to do to begin to investigate possible other roles for the trunk or torso - like genes? C a…

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Genetic Analysis: An Integrated Approach (3rd Edition)

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