EBK GENETICS: FROM GENES TO GENOMES
EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 18, Problem 25P

Nonhomologous end-joining (NHEJ) of a double-strand break almost always results in perfect resealing of the DNA lesion, without the loss or gain of nucleotide pairs. Yet CRISPR/Cas9, which produces double-strand breaks, is a highly efficient method of making small deletions or insertions at the targeted site. How can you resolve this apparent contradiction?

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EBK GENETICS: FROM GENES TO GENOMES

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