EBK GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260041255
Author: HARTWELL
Publisher: MCGRAW HILL BOOK COMPANY
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Chapter 18, Problem 24P
| a. | Figures 18.9 and 18.12 demonstrated methods to produce mouse knockouts and knockins, respectively.CRISPR/Cas9 can make the same knockouts and knockins, and most mouse geneticists would now choose to use this new technology instead of the other methods. Explain why, respectively CRISPR/Cas9 is an easier and more efficient way to perform targeted mutagenesis in mice. |
| b. | How could you use the CRISPR/Cas9 technique to obtain a conditional knockout of a gene’s function only in a specific tissue of a multicellular organism?  |
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(This is a 2-part work, Part 1 is done, only Part 2 is to be worked on at the bottom)Part 1 (Done): Describe the levels of structural hierarchy for the human body, starting with the organismal level and ending with the chemical level. In addition, you should make sure you link each level to the previous level, emphasizing the structural relationships.
The human body is organized into a structural hierarchy that progresses from the macroscopic organismal level down to the microscopic chemical level. Each level builds upon the previous one, creating increasingly complex structures. Below is the hierarchy, from largest to smallest, with explanations linking each level to its predecessor:
1. Organismal Level
The entire living human body.Relationship: All lower levels work together to sustain life at this highest level.
2. Organ System Level
Groups of organs working together to perform major functions.Examples: circulatory, nervous, digestive systems.Relationship: The organismal…
Describe the levels of structural hierarchy for the human body, starting with the organismal level and ending with the chemical level. In addition, you should make sure you link each level to the previous level, emphasizing the structural relationships.
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Chapter 18 Solutions
EBK GENETICS: FROM GENES TO GENOMES
Ch. 18 - Match each of the terms in the left column to the...Ch. 18 - Mice are usually gray, but a mouse geneticist has...Ch. 18 - Sometimes, genes transferred into the mouse genome...Ch. 18 - In mice, a group of so-called Hox genes encode...Ch. 18 - The fly eyes shown in Fig. 18.7 are malformed...Ch. 18 - This problem concerns a technique called enhancer...Ch. 18 - Fish and other organisms that live in the Arctic...Ch. 18 - a. Describe two ways you could potentially make a...Ch. 18 - Figure 18.6 shows a picture of Glofish ,...Ch. 18 - Some people are concerned about the possible...
Ch. 18 - The goal of the Knockout Mouse Project is to...Ch. 18 - Prob. 12PCh. 18 - Prob. 13PCh. 18 - a. Which genome manipulation technique would you...Ch. 18 - a. Diagram a knockin construct that could have...Ch. 18 - Prob. 16PCh. 18 - Prob. 17PCh. 18 - The transcription factor Pax6 is required...Ch. 18 - Mouse models for human genetic diseases are...Ch. 18 - One way to determine where inside a cell a protein...Ch. 18 - In Problem 5 in Chapter 17, you saw that a SNP...Ch. 18 - Scientists now routinely use CRISPR/Cas9 to make...Ch. 18 - Geneticists are currently considering using...Ch. 18 - a. Figures 18.9 and 18.12 demonstrated methods to...Ch. 18 - Nonhomologous end-joining NHEJ of a double-strand...Ch. 18 - One problem that researchers sometimes encounter...Ch. 18 - Researchers at the University of California at San...Ch. 18 - Prob. 28PCh. 18 - F. Port and S. Bullock at the University of...Ch. 18 - On Fig 18.14, locate the PAM site and identify the...Ch. 18 - Prob. 31PCh. 18 - Prob. 32PCh. 18 - Recall that Leber congenital amaurosis LCA, a form...Ch. 18 - One potential strategy for gene therapy to correct...Ch. 18 - Recently, scientists have used a mouse model for...
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