Effect of hemoglobin when substitution of valine for glutamic acid in primary structure of hemoglobin has to be identified. Concept introduction: Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins. Amino functional group is ( − N H 2 ) and carboxyl functional group is ( − C O O H ) and a R group is considered as side chain, when all these are bonded to same carbon atom. Primary structure of protein is a sequence in which the amino acids linked by peptide bond in a protein. Sickle-cell anemia is a hereditary disease caused by genetic difference that replaces one amino acid (glutamate) with another in each of the two polypeptide chains of the hemoglobin.

Question

Want to see the full answer?

Answer 1

Question

Chapter 18, Problem 18.69AP

Interpretation Introduction

Interpretation:

Effect of hemoglobin when substitution of valine for glutamic acid in primary structure of hemoglobin has to be identified.

Concept introduction:

Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.

Amino functional group is (−NH2) and carboxyl functional group is (−COOH) and a R group is considered as side chain, when all these are bonded to same carbon atom.

Primary structure of protein is a sequence in which the amino acids linked by peptide bond in a protein.

Sickle-cell anemia is a hereditary disease caused by genetic difference that replaces one amino acid (glutamate) with another in each of the two polypeptide chains of the hemoglobin.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

carbons in each of the structures below. For instance, the central carbon of chloromethylbutane (pictured 3. A chiral carbon is a carbon that is single-bonded to four different types of groups. Identify the chiral above) is a chiral carbon. (Can you see how the groups attached to it are all chemically different?) In each of the chiral molecules below, identify all the carbons that are chiral carbons by drawing a circle around each one of them. (a) the carbohydrate glucose H O (b) the carbohydrate fructose CH₂OH 1C H-C-OH 3 HO-C-H 4 H-C-OH 5 H-C-OH 6CH₂OH D-Glucose (linear form) (c) the amino acid leucine O O H3C. HO H H- -OH CH 3 NH2 H- -OH CH₂OH OH

We always include controls in the Annexin-V-GFP/Propidium Iodide flow cytometric assay to study apoptosis. List four types of controls in this assay. Why do we need these controls? Explain your answers. After the flow assay, if we like to examine the morphology of the viable, early apoptotic and late apoptotic cells by confocal microscopy, what can we do and what are the expected results?

3. (2 points) Your lab partner accidentally used a pen instead of a pencil to mark the baseline and label the lanes of their TLC plate. Briefly (1-2 sentences for each point) describe (a) what would happen to the ink when you develop the TLC plate; and (b) how this would affect the experiment. 1