Concept explainers
(a)
Interpretation:
At neutral
Concept Introduction:
Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.
Amino
Zwitter ion has both positive as well as negative charge, thus it is also called neutral dipolar ion.
Zwitter ion accepts proton in acidic condition and in basic condition zwitter ion lose electrons.
(b)
Interpretation:
At neutral
Concept Introduction:
Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.
Amino functional group is
Zwitter ion has both positive as well as negative charge, thus it is also called neutral dipolar ion.
Zwitter ion accepts proton in acidic condition and in basic condition zwitter ion lose electrons.
(c)
Interpretation:
At neutral
Concept introduction:
Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.
Amino functional group is
Zwitter ion has both positive as well as negative charge, thus it is also called neutral dipolar ion.
Zwitter ion accepts proton in acidic condition and in basic condition zwitter ion lose electrons.
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Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
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- a) This molecule is produced when what amino acid is transaminated? b) What are the one- and three-letter abbreviations for this amino acid?arrow_forwardWhat is the net average charge on the predominant form of lysine at pH values of (a) 2.0, (b) 5.0 and (c) 7.0? CLUE: draw the structure of lysine and show its different charged forms; then consider in which pH domains the pKa values for deprotonation/protonation occur.arrow_forwardHow many chiral carbons are present in this amino acid (aqueous form)? (Identify the following amino acid (at pH = 7.0): (COO-)–CH(NH3+)–CH2–CH2–CH2–CH2–(NH3+)) zero chiral carbons one chiral carbon two chiral carbons three chiral carbons four chiral carbonsarrow_forward
- Which of the following amino acids is most likely to be found on the outside of a soluble protein? Which is more likely to be found on the inside? Explain each answer. (Hint: Consider the effect of the amino acid side chain in each case and that the protein is folded up into its globularform.)(a) Leucine (b) Glutamate(c) Phenylalanine (d) Glutaminearrow_forwardConsider a short peptide with the sequence M-C-Q-L-Y-P-E-D-K. List the ionizable groups in this peptide, and the net charge of the whole peptide at pH a) 1.5, b) 7.0, and c)12.0.arrow_forwardUse the pka values, calculate the isoelectric point (pl) of the following amino acids. a) Leucine b) Arginine c) Aspartic acid d) Glutamic acid Amino Acid Alanine Arginine Asparagine Aspartic acid Cysteine Glutamic acid Glutamine Glycine Histidine Isoleucine Leucine Lysine Methionine Phenylalanine Proline Serine Threonine Tryptophan Tyrosine Valine pk, of a-COOH 2.35 2.01 2.02 2.10 2.05 2.10 2.17 2.35 1.77 2.32 2.33 2.18 2.28 2.58 2.00 2.21 2.09 2.38 2.20 2.29 pk of a-NH,* 9.87 9.04 8.80 9.82 10.25 9.47 9.13 9.78 9.18 9.76 9.74 8.95 9.21 9.24 10.60 9.15 9.10 9.39 9.11 9.72 pk of Side Chain 12.48 - 3.86 8.00 4.07 6.10 - 10.53 II 10.07 -arrow_forward
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