Concept explainers
Interpretation:
Example of a protein containing primarily alpha-helices and also identify the protein mentioned is globular or fibrous.
Concept introduction:
Many amino acids are linked together through amide bonds to form a biologically large molecule known to be proteins.
Amino functional group is
Secondary structure of protein is the repeating structural patterns (
Fibrous protein is a tough, water insoluble protein whose protein chains form fibers or sheets.
Globular protein is a water soluble protein whose chain is folded in a compact shape.
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Check out a sample textbook solutionChapter 18 Solutions
Fundamentals of General, Organic, and Biological Chemistry (8th Edition)
- Amino acids project from each polypeptide backbone in a β-sheet in an alternating fashion (oneabove the plane and the next below the plane – see Fig 3.8B). Consider the following proteinsequence: Leu-Lys-Val-Asp-Ile-Ser-Leu-Arg-Leu-Lys-Ile-Arg-Phe-Glu.a. Is there a pattern to these amino acids? If so, what is it? b. What does this sequence of amino acids mean for the hydrophobicity/hydrophilicity of theresulting β-sheet? c. Can you make a prediction about how the β-sheet will be arranged in higher levels of protein structure? If so, what prediction would you make?arrow_forwardAlpha helices are a type of secondary structure in proteins. What is the length of a 23.0 kDa single-stranded α-helical protein segment? Assume a mean residue mass of 110 Da. length: 209 Incorrect Åarrow_forwardWhich amino acids would you expect to find buried in the interior of peripheral membrane protein ?arrow_forward
- Give an example of a protein containing primarily alphahelices. Is this a fibrous or globular protein?arrow_forwardIn the figure below, protein 1 is located in the cytosol, and protein 2 is membrane bound. Give 3 specific examples from Figure 4-3 of amino acids that you might expect to find on the surface of protein 1. For protein 2, give three specific amino acids that you would expect to be on the surface near both points A and B (labeled with stars). To clarify, you should choose 3 amino acids for point A and also list three amino acids for point B. All of the amino acids you choose for Protein 2 must be different from those that you choose for Protein 1. Rationalize your choices by discussing the amino acids you chose, and their properties in a few sentences. Protein 1 Protein 2arrow_forwardConsider protein folding that results when the following components interact: Where the solution is at a pH of 7, green (thick-dotted line) represents aspartic acid (R group contains a carboxylic acid with pKa = 4), orange (thick-solid line) represents lysine (R group contains an amine with pKa = 10), and blue (thin-solid line) represents hydrophilic groups. Rank the three complexes in order from lowest to highest dissociation constants Kd (low Kd values correspond to good binding constants and low energy, while high Kd values correspond to low binding constants and high energy) as determined by intermolecular charge-charge interactions. For those complexes with charge-charge interactions being equal, look at the possibility for the formation of hydrogen bonds via carboxylic acid dimers (only possible when the carboxylic acid is protonated) which are low energy structures.arrow_forward
- Disulfide linkages are uncommon in cytoplasmic proteins, whereas they are common in extracellular proteins. Why?arrow_forwardHOW MANY DIFFERENT PROTEINS CAN BE CONSTRUCTED THAT ARE EXACTLY FOUR AMINO ACIDS LONG? (HINT: THERE ARE 20 POSSIBLE AMINO ACIDS.)arrow_forwardConsider beta-sheet comprised of twelve amino acid residues (two strands of six residues each). How many hydrogen bonds should be formed between backbone atoms in this sheet?arrow_forward
- When a protein was denatured and lost its function due to its spatial structures were disrupted. Which of the following was disrupted during the denaturing process?arrow_forwardGlycophorin is an integral membrane protein found on the surface of red blood cells that is important for binding to the malaria parasite. Name three different amino acids that you might expect to be present in the region of this protein that spans the lipid bilayer and name three different amino acids that you would expect to be absent from this region. For each group, describe what those amino acids have in common that distinguishes them from the other group.arrow_forwardMulti-adhesive matrix proteins form adhesive bridges between what type of components or structures? Give an example of such an ECM protein?arrow_forward
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