(a) Interpretation: The structure of the conjugate base of warfarin is to be drawn. Concept introduction: Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

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Answer 1

Question

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

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Answer 2

Question

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

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Answer 3

Question

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

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Answer 4

Question

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

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Answer 5

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 6

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 7

Chapter 18, Problem 18.51AP

Interpretation Introduction

(a)

Interpretation:

The structure of the conjugate base of warfarin is to be drawn.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The unusual low pKa value of warfarin on the basis of resonance arguments is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 10

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 11

Interpretation Introduction

(c)

Interpretation:

Whether at physiological pH the predominant form of warfarin is enol or conjugate base is to be stated.

Concept introduction:

Warfarin is used as one of the anticoagulant agents. In the market, it is sold as Coumadin brand. It is not advisable to use it in pregnancy. It has adverse side effects like bleeding, purple toe syndrome, calcification. The X-ray studies confirm that it exists as a cyclic hemiketal tautomeric form.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 18 - Prob. 18.1P Ch. 18 - Prob. 18.2P Ch. 18 - Prob. 18.3P Ch. 18 - Prob. 18.4P Ch. 18 - Prob. 18.5P Ch. 18 - Prob. 18.6P Ch. 18 - Prob. 18.7P Ch. 18 - Prob. 18.8P Ch. 18 - Prob. 18.9P Ch. 18 - Prob. 18.10P

Solution Summary: The author explains the structure of the conjugate base of warfarin.

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Chapter 18 Solutions