Human Biology: Concepts and Current Issues (8th Edition)
8th Edition
ISBN: 9780134042435
Author: Michael D. Johnson
Publisher: PEARSON
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Chapter 17, Problem 2QC
How far should we go–to what lengths and at what expense–to prolong life? Are there limits?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
3.
In the tomato, red fruit (O+) is dominant over orange fruit (0), and yellow flowers (W+) are dominant over white
flowers (w). A cross was made between true-breeding plants with red fruit and yellow flowers, and plants with
orange fruit and white flowers. The F₁ plants were then crossed to plants with orange fruit and white flowers, which
produced the following results:
a.
b.
333 red fruit, yellow flowers
64 red fruit, white flowers
58 orange fruit, yellow flowers
350 orange fruit, white flowers
Conduct a chi-square analysis to demonstrate that these two genes DO NOT assort independently. Make sure
to interpret the P value obtained from your chi-square test.
Calculate and provide the map distance (in map units) between the two genes.
Chapter 17 Solutions
Human Biology: Concepts and Current Issues (8th Edition)
Ch. 17 - How do you feel about the creation and then...Ch. 17 - How far should we go–to what lengths and at what...Ch. 17 - Describe how DNA is replicated before cell...Ch. 17 -
2. Compare and contrast the processes of...Ch. 17 - Explain what mutations are and the role of DNA...Ch. 17 - Name the four phases of mitosis and describe...Ch. 17 -
5. Explain why only one large egg is formed...Ch. 17 - Describe what is meant by selective gene...Ch. 17 - Explain how factors present in the environment can...Ch. 17 - Describe how ribosomes contribute to the formation...
Ch. 17 - Prob. 9CRCh. 17 - Prob. 10CRCh. 17 - What would be the outcome if a cell completed...Ch. 17 - Prob. 2TYCh. 17 - Prob. 3TYCh. 17 - Prob. 4TYCh. 17 - Which of the following are listed in order from...Ch. 17 - Prob. 6TYCh. 17 - Which is likely to be the shortest chain of...Ch. 17 - How many different amino acids could be encoded if...Ch. 17 - Prob. 9TYCh. 17 - Why do cells within an organism differentiate,...Ch. 17 - Which method of cloning is most similar to the way...Ch. 17 - Prob. 12TYCh. 17 - Prob. 13TYCh. 17 - Prob. 14TYCh. 17 -
15. How does the production of sperm differ from...Ch. 17 - Prob. 1AWKCh. 17 - Prob. 2AWKCh. 17 - Prob. 3AWKCh. 17 - Prob. 4AWKCh. 17 - Mitochondria contain their own DNA that is...Ch. 17 - Bacteria can reproduce by simple cell division....
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