Microbiology: An Introduction
Microbiology: An Introduction
12th Edition
ISBN: 9780321929150
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case
Publisher: PEARSON
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Chapter 16, Problem 3CAE

Leukocyte adherence deficiency (LAD) is an inherited disease resulting in the inability of neutrophils to recognize C3b-bound microorganisms. What are the most likely consequences of LAD?

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Therapeutic agents are currently being investigated that block the action of selectins in order to prevent the pathological effects resulting from leukocyte entry into sites of inflammation. These agents are molecules that inhibit selectin. Describe molecules that might be effective. (Information: Glycoproteins are an important class of proteins. There are many families of glycoproteins: lectins and selectins are examples.)
Describe stages for the extravasation of neutrophils during inflammation. Include in your description the roles played by selectins and integrins.
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