EBK FUNDAMENTALS OF GENERAL, ORGANIC, A
8th Edition
ISBN: 8220102895805
Author: Peterson
Publisher: PEARSON
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Chapter 15, Problem 15.62CP
Interpretation Introduction
Interpretation:
The polarity should be determined given the 2-Butanone and 2-heptanone and whether it is soluble or insoluble in water it should be explained.
Concept Introduction:
Polarity: It is a well separation of electric charge leading to a molecule or chemical compounds having an electrical dipole moment. Generally the polar molecules must contain polar bonds due to a different in electronegative between the bonded atoms.
Solubility: The general rule that in solubility is like dissolve like, in other words, polar compounds dissolve in polar solvents, and non-polar compounds dissolve in non-polar solvents.
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The beta-lactamase hydrolyzes the lactam-ring in penicillin. Describe the mechanism
of hydrolysis, insuring to include the involvement of S, D, & K in the reaction sequence. Please help
To map the active site of beta-lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
Why doesn't D in this hexapeptide not participate in the hydrolysis of the beta-lactam ring even though S, K, and D are involved in the catalyst?
To map the active site of -lactamase, the enzyme was hydrolyzed with trypsin to yield a hexapeptide (P1) with the following amino acids. Glu, Lys, Leu, Phe, Met, and Ser. Treatment of P1 with phenyl isothiocyanate yielded a PTH derivative of phenylalanine and a peptide (P2). Treatment of P1 with cyanogenbromide gave an acidic tetrapeptide (P3) and a dipeptide (P4).Treatment of P2 with 1-fluoro-2,4-dinitrobenzene, followed by complete hydrolysis, yields N-2,4-dinitrophenyl-Glu. P1, P2, and P3 contain the active site serine.
Using the experimental results described above derive the primary sequence of the active site hexapeptide. Please help!
Chapter 15 Solutions
EBK FUNDAMENTALS OF GENERAL, ORGANIC, A
Ch. 15.1 - Prob. 15.1PCh. 15.1 - Prob. 15.2PCh. 15.2 - Draw structures corresponding to the following...Ch. 15.2 - Prob. 15.1CIAPCh. 15.2 - Prob. 15.2CIAPCh. 15.2 - Prob. 15.4PCh. 15.2 - Draw the line structures and provide common names...Ch. 15.2 - Prob. 15.6KCPCh. 15.3 - For each compound shown next (ad), indicate...Ch. 15.3 - Prob. 15.8KCP
Ch. 15.4 - Prob. 15.9KCPCh. 15.5 - Indicate whether the following compounds will give...Ch. 15.6 - Draw line structures of the following compounds...Ch. 15.6 - Prob. 15.12PCh. 15.7 - Prob. 15.13PCh. 15.7 - Prob. 15.14PCh. 15.7 - Prob. 15.15PCh. 15.7 - Draw the structure of each acetal or ketal final...Ch. 15.7 - Prob. 15.17PCh. 15.7 - Prob. 15.18PCh. 15.7 - Prob. 15.19PCh. 15.7 - Prob. 15.1MRPCh. 15.7 - Prob. 15.2MRPCh. 15.7 - Prob. 15.3MRPCh. 15.7 - Prob. 15.3CIAPCh. 15.7 - (a) What are mirotubules? (b) Why would drugs that...Ch. 15.7 - Tetrodotoxin, found in the puffer fish, has been...Ch. 15 - Prob. 15.20UKCCh. 15 - Prob. 15.21UKCCh. 15 - Prob. 15.22UKCCh. 15 - Prob. 15.23UKCCh. 15 - Prob. 15.24UKCCh. 15 - Prob. 15.25UKCCh. 15 - ALDEHYDESAND KETONES (SECTIONS 15.1 AND 15.2)...Ch. 15 - Draw a structure for a compound that meets each of...Ch. 15 - Prob. 15.28APCh. 15 - Prob. 15.29APCh. 15 - Draw structures corresponding to the following...Ch. 15 - Draw structures corresponding to the following...Ch. 15 - Prob. 15.32APCh. 15 - Prob. 15.33APCh. 15 - The following names are incorrect. What is wrong...Ch. 15 - Prob. 15.35APCh. 15 - Prob. 15.36APCh. 15 - Prob. 15.37APCh. 15 - Prob. 15.38APCh. 15 - Prob. 15.39APCh. 15 - Prob. 15.40APCh. 15 - Draw the structures of the aldehydes that might be...Ch. 15 - Write the structures of the hemiacetal or...Ch. 15 - Write the structures of the hemiacetal or...Ch. 15 - Prob. 15.44APCh. 15 - Prob. 15.45APCh. 15 - Prob. 15.46APCh. 15 - Prob. 15.47APCh. 15 - Prob. 15.48APCh. 15 - Prob. 15.49APCh. 15 - Prob. 15.50CPCh. 15 - Prob. 15.51CPCh. 15 - Prob. 15.52CPCh. 15 - Prob. 15.53CPCh. 15 - Prob. 15.54CPCh. 15 - Name the following compounds: (a) (b) (c) (be sure...Ch. 15 - Draw the structural formulas of the following...Ch. 15 - Prob. 15.57CPCh. 15 - Complete the following equations (refer to Summary...Ch. 15 - Prob. 15.59CPCh. 15 - How could you differentiate between 3-hexanol and...Ch. 15 - The liquids 1-butanol and butanal have similar...Ch. 15 - Prob. 15.62CPCh. 15 - Prob. 15.63GPCh. 15 - Prob. 15.64GPCh. 15 - Using the ketone structural form of fructose...Ch. 15 - Prob. 15.66GP
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