Genetic Analysis: An Integrated Approach (2nd Edition)
Genetic Analysis: An Integrated Approach (2nd Edition)
2nd Edition
ISBN: 9780321948908
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 13, Problem 6P
Summary Introduction

To analyze:

In the hybrid dysgenesis of D. melanogaster, it shows the transposition repressor coded by the P element.

This repressor limits the number of P elements in a genome.

What is the advantage of limiting the P elements in the genome?

Introduction:

Transposition is the movement of transposable elements from one site to another.

These are DNA sequences having various sizes and sequence arrangement. They move throughout the genome to increase their own copy number. In the 1930s, Barbara McClintock discovered transposition in studies of a mutant phenotype of kernel color in maize. Transposable elements create mutations by their insertion into wild type alleles or functional genes.

P - elements in Drosophila are transposable elements that are transposed only in the germ cells.

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22. Which of the following mutant proteins is expected to have a dominant negative effect when over-   expressed in normal cells?   a. mutant PI3-kinase that lacks the SH2 domain but retains the kinase function   b. mutant Grb2 protein that cannot bind to RTK   c. mutant RTK that lacks the extracellular domain   d. mutant PDK that has the PH domain but lost the kinase function   e. all of the above
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Chapter 13 Solutions

Genetic Analysis: An Integrated Approach (2nd Edition)

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