Biochemistry: The Molecular Basis of Life
6th Edition
ISBN: 9780190209896
Author: Trudy McKee, James R. McKee
Publisher: Oxford University Press
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Chapter 13, Problem 50FB
Summary Introduction
To review:
The given blank space in the statement, “In addition to C3 photosynthesis (the most common form), there are two other mechanisms for fixing carbon dioxide. These are C4
Introduction:
Carbon fixation is the process where inorganic carbon is incorporated into organic compounds. The most prominent way by which carbon is fixed in plants is photosynthesis. Other cycles, like C3 or Calvin cycle, also utilize the inorganic carbon for the
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Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvatedehydrogenase complex, resulting in acetyl-CoA and CO2. Provide a full mechanismfor this reaction utilizing the TPP cofactor. Include the roles of all cofactors.
B- Vitamins are converted readily into important metabolic cofactors. Deficiency inany one of them has serious side effects.
a. The disease beriberi results from a vitamin B 1 (Thiamine) deficiency and ischaracterized by cardiac and neurological symptoms. One key diagnostic forthis disease is an increased level of pyruvate and α-ketoglutarate in thebloodstream. How does this vitamin deficiency lead to increased serumlevels of these factors?
b. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 5 deficiency?
c. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 2 /B 3 deficiency?
Draw the Krebs Cycle and show the entry points for the amino acids Alanine,Glutamic Acid, Asparagine, and Valine into the Krebs Cycle - (Draw the Mechanism).
How many rounds of Krebs will be required to waste all Carbons of Glutamic Acidas CO2?
Chapter 13 Solutions
Biochemistry: The Molecular Basis of Life
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