EBK ESSENTIAL ORGANIC CHEMISTRY
EBK ESSENTIAL ORGANIC CHEMISTRY
3rd Edition
ISBN: 8220100659461
Author: Bruice
Publisher: PEARSON
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Chapter 13, Problem 32P
Interpretation Introduction

Interpretation: Moles of malonyl-CoA required for the synthesis of one mole of Arachidic  acid has to be determined.

Concept introduction:

Fatty acids are aliphatic mono-carboxylic acids that are mostly obtained from the hydrolysis of natural fats and oils. They have a general formulaEBK ESSENTIAL ORGANIC CHEMISTRY, Chapter 13, Problem 32P , n is mostly an even number of carbon atoms (4 to 20) with a few exceptions that have an odd number.

In the synthesis of fatty acids, firstly acetyl thioester and malonyl thioester combines to form a four carbon thioester.  This thioester reacts with malonyl thioester.  Each malonyl thioester adds two carbon.  Each time malonyl thioester is added, two carbon atoms are increased in the fatty acid chain.

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16. The proton NMR spectral information shown in this problem is for a compound with formula CioH,N. Expansions are shown for the region from 8.7 to 7.0 ppm. The normal carbon-13 spec- tral results, including DEPT-135 and DEPT-90 results, are tabulated: 7 J Normal Carbon DEPT-135 DEPT-90 19 ppm Positive No peak 122 Positive Positive cus и 124 Positive Positive 126 Positive Positive 128 No peak No peak 4° 129 Positive Positive 130 Positive Positive (144 No peak No peak 148 No peak No peak 150 Positive Positive してし
3. Propose a synthesis for the following transformation. Do not draw an arrow-pushing mechanism below, but make sure to draw the product of each proposed step (3 points). + En CN CN
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