Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 13, Problem 2P
Interpretation Introduction
Interpretation:
The fate of each labeled carbon in pyruvate labeled with with carbon 1 (carboxyl), carbon 2 (carbonyl), and carbon 3 (methyl) during one turn of the citric acid cycle should be determined.
Concept Introduction:
The pyruvate from glycolysis enters the citric acid cycle for the complete breakdown of glucose molecule which gets first catalyzed by acetyl CoA to produce citrate and then isocitrate which gets oxidized to 2- oxoglutarate which produces succinate through succinyl CoA. Finally, oxaloacetate is produced through malate which gets produced from fumarate or fumaric acid.
Pictorial representation:
The citric acid cycle can be represented in a pictorial manner as:
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