Chapter 13, Problem 9P

Interpretation Introduction

(a) Interpretation:

The activation of pyruvate carboxylase by acetyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(b) Interpretation:

The activation of pyruvate dehydrogenase kinase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(c) Interpretation:

The inhibition of isocitrate dehydrogenase by NADH should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(d) Interpretation:

The activation of isocitrate dehydrogenase by ADP should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(e) Interpretation:

The inhibition of $\alpha$ -ketoglutarate dehydrogenase by succinyl-CoA should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.

Interpretation Introduction

(f) Interpretation:

The activation of pyruvate dehydrogenase phosphatase by Ca²+ should be explained.

Concept introduction:

The co-operative interaction where the binding of one molecule of a substance influences the binding of next molecules of the same kind is described to as a homotopic allosteric interaction; similarly, a heterotopic allosteric interaction involves the co-operative interaction among the different type of substances binding with a target protein.