Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Textbook Question
Chapter 13, Problem 15RQ
Which adult structure(s) arises from the diencephalon?
- thalamus, hypothalamus, retina
- midbrain, pons, medulla
- pons and cerebellum
- cerebmm
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
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F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 13 Solutions
Anatomy & Physiology
Ch. 13 - Watch this animation...Ch. 13 - Watch this video...Ch. 13 - Watch this video...Ch. 13 - Watch this video...Ch. 13 - Watch this video...Ch. 13 - Compared with the nearest evolutionary relative,...Ch. 13 - Watch this animation...Ch. 13 - Watch this video...Ch. 13 - Watch this animation...Ch. 13 - Figure 13.20 If you zoom in on the DRG, you can...
Ch. 13 - Figure 13.22 To what structures in a skeletal...Ch. 13 - Visit this site...Ch. 13 - Aside from the nervous system, which other organ...Ch. 13 - Which primary vesicle of the embryonic nervous...Ch. 13 - Which adult structure(s) arises from the...Ch. 13 - Which non-nervous tissue develops from the...Ch. 13 - Which structure is associated with the embryologic...Ch. 13 - Which lobe of the cerebral cortex is responsible...Ch. 13 - What region of the diencephalon coordinates...Ch. 13 - What level of the brain stem is the major input to...Ch. 13 - What region of the spinal cord contains motor...Ch. 13 - Brodmanns areas map different regions of the...Ch. 13 - What blood vessel enters the cranium to supply the...Ch. 13 - Which layer of the meninges surrounds and supports...Ch. 13 - What type of glial cell is responsible for...Ch. 13 - Which portion of the ventricular system is found...Ch. 13 - What condition causes a stroke? inflammation of...Ch. 13 - What type of ganglion contains neurons that...Ch. 13 - Which ganglion is responsible for cutaneous...Ch. 13 - What is the name for a bundle of axons within a...Ch. 13 - Which cranial nerve does not control functions in...Ch. 13 - Which of these structures is not under direct...Ch. 13 - Studying the embryonic development of the nervous...Ch. 13 - What happens in development that suggests that...Ch. 13 - Damage to specific regions of the cerebral cortex,...Ch. 13 - Why do the anatomical inputs to the cerebellum...Ch. 13 - Why can the circle of Willis maintain perfusion of...Ch. 13 - Meningitis is an inflammation of the meninges that...Ch. 13 - Why are ganglia and nerves not surrounded by...Ch. 13 - Testing for neurological function involves a...
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