Anatomy & Physiology
Anatomy & Physiology
1st Edition
ISBN: 9781938168130
Author: Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher: OpenStax College
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Chapter 13, Problem 38CTQ

Meningitis is an inflammation of the meninges that can have severe effects on neurological function. Why is infection of this structure potentially so dangerous?

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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
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Chapter 13 Solutions

Anatomy & Physiology

Ch. 13 - Figure 13.22 To what structures in a skeletal...Ch. 13 - Visit this site...Ch. 13 - Aside from the nervous system, which other organ...Ch. 13 - Which primary vesicle of the embryonic nervous...Ch. 13 - Which adult structure(s) arises from the...Ch. 13 - Which non-nervous tissue develops from the...Ch. 13 - Which structure is associated with the embryologic...Ch. 13 - Which lobe of the cerebral cortex is responsible...Ch. 13 - What region of the diencephalon coordinates...Ch. 13 - What level of the brain stem is the major input to...Ch. 13 - What region of the spinal cord contains motor...Ch. 13 - Brodmanns areas map different regions of the...Ch. 13 - What blood vessel enters the cranium to supply the...Ch. 13 - Which layer of the meninges surrounds and supports...Ch. 13 - What type of glial cell is responsible for...Ch. 13 - Which portion of the ventricular system is found...Ch. 13 - What condition causes a stroke? inflammation of...Ch. 13 - What type of ganglion contains neurons that...Ch. 13 - Which ganglion is responsible for cutaneous...Ch. 13 - What is the name for a bundle of axons within a...Ch. 13 - Which cranial nerve does not control functions in...Ch. 13 - Which of these structures is not under direct...Ch. 13 - Studying the embryonic development of the nervous...Ch. 13 - What happens in development that suggests that...Ch. 13 - Damage to specific regions of the cerebral cortex,...Ch. 13 - Why do the anatomical inputs to the cerebellum...Ch. 13 - Why can the circle of Willis maintain perfusion of...Ch. 13 - Meningitis is an inflammation of the meninges that...Ch. 13 - Why are ganglia and nerves not surrounded by...Ch. 13 - Testing for neurological function involves a...

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