Chemistry In Context
9th Edition
ISBN: 9781259638145
Author: Fahlman, Bradley D., Purvis-roberts, Kathleen, Kirk, John S., Bentley, Anne K., Daubenmire, Patrick L., ELLIS, Jamie P., Mury, Michael T., American Chemical Society
Publisher: Mcgraw-hill Education,
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Question
Chapter 12, Problem 44Q
Interpretation Introduction
Interpretation:
Reason for why thalidomide was banned and FDA rejected the approval of marketing of this drug in US several times until recently and the purpose of approval of using thalidomide has to be explained.
Concept introduction:
Drugs: Drugs are molecules which are taken from an external source to change the normal functioning of the body. The action of drug is in molecular level and the design of many drugs are in such a way that it mimics a particular neurotransmitter or hormone. Drugs bind with receptors showing an increased or decreased effect.
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Arrange the solutions in order of increasing acidity. (Note that K (HF) = 6.8 x 10 and K (NH3) = 1.8 × 10-5)
Rank solutions from least acidity to greatest acidity. To rank items as equivalent, overlap them.
▸ View Available Hint(s)
Least acidity
NH&F NaBr NaOH
NH,Br NaCIO
Reset
Greatest acidity
1. Consider the following molecular-level diagrams of a titration.
O-HA molecule
-Aion
°°
о
°
(a)
о
(b)
(c)
(d)
a. Which diagram best illustrates the microscopic representation for the
EQUIVALENCE POINT in a titration of a weak acid (HA) with sodium.
hydroxide?
(e)
Answers to the remaining 6 questions will be hand-drawn on paper and submitted as a single
file upload below:
Review of this week's reaction:
H₂NCN (cyanamide) + CH3NHCH2COOH (sarcosine) + NaCl, NH4OH, H₂O --->
H₂NC(=NH)N(CH3)CH2COOH (creatine)
Q7. Draw by hand the reaction of creatine synthesis listed above using line structures without showing
the Cs and some of the Hs, but include the lone pairs of electrons wherever they apply. (4 pts)
Q8. Considering the Zwitterion form of an amino acid, draw the Zwitterion form of Creatine. (2 pts)
Q9. Explain with drawing why the C-N bond shown in creatine structure below can or cannot rotate. (3
pts)
NH2(C=NH)-N(CH)CH2COOH
This bond
Q10. Draw two tautomers of creatine using line structures. (Note: this question is valid because problem
Q9 is valid). (4 pts)
Q11. Mechanism. After seeing and understanding the mechanism of creatine synthesis, students should
be ready to understand the first half of one of the Grignard reactions presented in a past…
Chapter 12 Solutions
Chemistry In Context
Ch. 12.1 - Skill Building Finding Equilibrium Glucose and...Ch. 12.1 - Prob. 12.3YTCh. 12.1 - Prob. 12.4YTCh. 12.2 - Prob. 12.5YTCh. 12.2 - Prob. 12.6YTCh. 12.2 - A practicing scientist must Judge a potential...Ch. 12.3 - Prob. 12.8YTCh. 12.3 - Skill Building Checking on Carbon a. Examine the...Ch. 12.3 - Prob. 12.10YTCh. 12.3 - Prob. 12.11YT
Ch. 12.3 - Prob. 12.12YTCh. 12.4 - Prob. 12.13YTCh. 12.4 - Skill Building Functional Groups in Dopamine Draw...Ch. 12.4 - Prob. 12.15YTCh. 12.5 - Prob. 12.16YTCh. 12.5 - Prob. 12.17YTCh. 12.6 - Prob. 12.18YTCh. 12.6 - Prob. 12.19YTCh. 12.6 - The structures of proteins, such as the ones shown...Ch. 12.7 - Reconsider your work in past chapters. List three...Ch. 12.7 - Prob. 12.22YTCh. 12.7 - Prob. 12.23YTCh. 12.8 - Prob. 12.24YTCh. 12.8 - Prob. 12.25YTCh. 12.9 - Skill Building Ester Formation Draw structural...Ch. 12.9 - Prob. 12.27YTCh. 12.9 - You Decide Supersize My Aspirin A friend who...Ch. 12.9 - Modern methods of drug discovery involve...Ch. 12.10 - Make two lists of drugs for each of the two...Ch. 12.10 - See for yourself the shapes of drug molecules by...Ch. 12.10 - Prob. 12.33YTCh. 12.10 - Prob. 12.34YTCh. 12 - Scientific Practices Follow the Hormone Using the...Ch. 12 - The field of chemistry has many sub-disciplines....Ch. 12 - Prob. 2QCh. 12 - Prob. 4QCh. 12 - Nitrous acid (HNO2) has a Ka value of 4.0 10 4,...Ch. 12 - Use the Henderson-Hasselbalch equation and Table...Ch. 12 - Write the structural formula and line-angle...Ch. 12 - Prob. 8QCh. 12 - Prob. 9QCh. 12 - Prob. 10QCh. 12 - Prob. 11QCh. 12 - Prob. 12QCh. 12 - Estradiol is relatively insoluble in water but...Ch. 12 - Prob. 14QCh. 12 - Prob. 15QCh. 12 - Prob. 16QCh. 12 - Define and relate the two terms: hormone and...Ch. 12 - Refer to Figure 11.17. Select two examples of...Ch. 12 - Prob. 19QCh. 12 - Molecules as diverse as cholesterol, sex hormones,...Ch. 12 - Prob. 21QCh. 12 - Prob. 22QCh. 12 - Prob. 23QCh. 12 - Sulfanilamide is the simplest sulfa drug, a type...Ch. 12 - Explain why an equilibrium constant cannot tell...Ch. 12 - Use the information in Table 12.1 to redraw Figure...Ch. 12 - Draw structural formulas for each of these...Ch. 12 - In Your Turn 12.12, you were asked to draw...Ch. 12 - Prob. 29QCh. 12 - Prob. 30QCh. 12 - Prob. 31QCh. 12 - Prob. 32QCh. 12 - Prob. 34QCh. 12 - Prob. 35QCh. 12 - Prob. 36QCh. 12 - Prob. 37QCh. 12 - Prob. 38QCh. 12 - The text states that some racemic mixtures contain...Ch. 12 - Prob. 40QCh. 12 - Prob. 41QCh. 12 - Prob. 44QCh. 12 - Prob. 47QCh. 12 - Prob. 49QCh. 12 - Dorothy Crowfoot Hodgkin first determined the...Ch. 12 - Prob. 52Q
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