Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 11.5, Problem 4RIA
Retrieve, Infer, Apply
In what eukaryotic organelle is the TCA cycle found? Where is the cycle located in bacterial and archaeal cells?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 11 Solutions
Prescott's Microbiology
Ch. 11.1 - Retrieve, Infer, Apply Discuss the ways in which...Ch. 11.1 - Describe the nutritional requirements of the major...Ch. 11.1 - Retrieve, Infer, Apply Compare...Ch. 11.1 - Retrieve, Infer, Apply What are the three major...Ch. 11.2 - Is NAD+ reduced to NADH in the catabolic or...Ch. 11.2 - Prob. 1RIACh. 11.2 - Why is it to a cells advantage to catabolize...Ch. 11.2 - Prob. 3RIACh. 11.4 - Which reactions are examples of substrate-level...Ch. 11.4 - For what kinds of reactions is NADPH used?
Ch. 11.4 - For what macromolecule is ribose 5-phosphate a...Ch. 11.4 - Summarize the major features of the...Ch. 11.4 - Prob. 2RIACh. 11.5 - Identify the substrate and products of the TCA...Ch. 11.5 - What chemical intermediate links pyruvate to the...Ch. 11.5 - Prob. 3RIACh. 11.5 - Retrieve, Infer, Apply In what eukaryotic...Ch. 11.5 - Why is it desirable for a microbe with the...Ch. 11.6 - Prob. 1MICh. 11.6 - Prob. 2MICh. 11.6 - Prob. 1RIACh. 11.6 - Describe the current model of oxidative...Ch. 11.6 - Prob. 3RIACh. 11.6 - Prob. 4RIACh. 11.7 - Prob. 1RIACh. 11.7 - Prob. 2RIACh. 11.7 - Prob. 3RIACh. 11.8 - Prob. 1MICh. 11.8 - Prob. 1RIACh. 11.8 - Prob. 2RIACh. 11.8 - Briefly describe alcoholic, lactic acid, mixed...Ch. 11.8 - Prob. 4RIACh. 11.8 - Prob. 5RIACh. 11.9 - What is the difference between a hydrolase and...Ch. 11.9 - Prob. 2MICh. 11.9 - Retrieve, Infer, Apply Briefly discuss the ways in...Ch. 11.9 - Prob. 2RIACh. 11.9 - Retrieve, Infer, Apply Describe how a...Ch. 11.10 - How do chemolithotrophs obtain their ATP and...Ch. 11.10 - Prob. 2RIACh. 11.10 - Why can hydrogen-oxidizing bacteria and archaea...Ch. 11.10 - What is reverse electron flow and why do many...Ch. 11.10 - Arsenate is a compound that inhibits...Ch. 11.11 - When electrons from P700 are used to reduce NADP+,...Ch. 11.11 - Define the following terms: light reactions, dark...Ch. 11.11 - Prob. 2RIACh. 11.11 - What is the function of accessory pigments?Ch. 11.11 - Prob. 4RIACh. 11.11 - Compare and contrast anoxygenic phototrophy and...Ch. 11.11 - Prob. 6RIACh. 11 - Without looking in chapters 21 and 22, predict...Ch. 11 - From an evolutionary perspective, discuss why most...Ch. 11 - How would you isolate a thermophilic...Ch. 11 - Certain chemicals block ATP synthesis by allowing...Ch. 11 - Prob. 5CHICh. 11 - A cyanobacterium having photosystem I but not...Ch. 11 - Review the description of the Berkeley Pit Lake in...Ch. 11 - The archaeon Metallosphaera sedula is of great...Ch. 11 - Nitrite-oxidizing bacteria have been thought to be...
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