Genetic Analysis: An Integrated Approach (3rd Edition)
Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
bartleby

Concept explainers

bartleby

Videos

Textbook Question
Book Icon
Chapter 10, Problem 32P

A healthy couple with a history of three previous spontaneous abortions has just had a child with  cri-du-chat the syndrome, a disorder caused by a terminal deletion of the chromosome 5 . Their physician orders karyotype analysis of both parents and of the child. The karyotype results for chromosomes   5 and   12 are shown here.

Chapter 10, Problem 32P, A healthy couple with a history of three previous spontaneous abortions has just had a child with

Are the chromosomes in the child consistent with those expected in a case of cri-du-chat syndrome? Explain your reasoning.

Which parent has an abnormal karyotype? How can you tell? What is the nature of the abnormality?

Why does this parent have a normal phenotype?

Diagram the pairing of the abnormal chromosomes.

What segregation pattern occurred to produce the gamete involved in fertilization of the child with cri-du-chat syndrome?

What is the approximate probability that the next child of this couple will have cri-du-chat a syndrome?

Do the karyotypes of the parents help explain the occurrence of the three previous spontaneous abortions? Explain.

Blurred answer
Students have asked these similar questions
The Klinefelter syndrome (disomy of the X chromosome in males) is a genetic disease caused by aneuploidy of the sex chromosomes in humans. Patients with the 47,XXY karyotype are male. Describe two genetic scenarios leading to patients with the Klinefelter syndrome.
A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. a. List all the different types of gametes that might be produced by the man. b. What types of zygotes will develop when each of gametes produced by the man fuses with a normal gamete produced by the woman? c. If trisomies and monosomies entailing chromosomes 13 and 22 are lethal, approximately what proportion of the surviving offspring are expected to be carriers of the translocation?
A normal female is discovered with 45 chromosomes, one of which exhibits a Robertsonian translocation containing most of chromosomes 15 and 21. Discuss the possible outcomes in her offspring when her husband contains a normal karyotype.

Chapter 10 Solutions

Genetic Analysis: An Integrated Approach (3rd Edition)

Knowledge Booster
Background pattern image
Biology
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
SEE MORE QUESTIONS
Recommended textbooks for you
Text book image
Human Biology (MindTap Course List)
Biology
ISBN:9781305112100
Author:Cecie Starr, Beverly McMillan
Publisher:Cengage Learning
Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY