Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 10, Problem 15P
A normal chromosome and its homolog carrying a paracentric inversion are given. The dot (•) represents the centromere.
Normal ABC •DEFGHIJK
Inversion abc •djihgfek
Diagram the alignment of chromosomes during prophase I.
Assume a crossover takes place in the region between F and G. Identify the gametes that are formedfollowing this crossover, and indicate which gametes are viable.
Assume a crossover takes place in the region between A and B. Identify the gametes that are formed by this crossover event, and indicate which gametes are viable.
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In Figure 17-28, what would be the consequence of acrossover between the centromere and locus A?
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An inversion heterozygote has homologous chromosomes with the
following linkage arrangements:³
b
• а
b
e
a. What type of inversion is it?
b.
Draw the configuration of the chromosomes at synapsis of Prophase I.
a
с
f
d
e
d
f
с
g
c. If a four-strand double crossover occurs in the areas c-d (including
chromatids 2 and 3) and e-f (including chromatids 1 and 4), what are
the meiotic products?
d. Repeat for a three-strand double crossover c-d (chromatids 2 and 3),
and f-g (chromatids 1 and 3).
e. For both types of double crossovers will any of the meiotic products
be viable? If so which?
Inversions are known to affect crossing-over. The following homologs have the indicated order (the filled and open circles indicate centromeres):
• (A B C D E)
o (A D C B E)
b. Diagram the alignment of these chromosomes during meiosis.
Chapter 10 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 10 - 10.1 Give descriptions for the following...Ch. 10 - 10.2 The human genome contains contains base...Ch. 10 - In eukaryotic DNA, Where are you most likely to...Ch. 10 - 10.4 Describe the importance of light and dark G...Ch. 10 - Human late prophase karyotypes have about 2000...Ch. 10 - Prob. 6PCh. 10 - From the following list, identify the types...Ch. 10 - 10.8 If the haploid number for a plant species is...Ch. 10 - Mating between a male donkey (2n=64) and a female...Ch. 10 - A researcher interested in studying a human gene...
Ch. 10 - 10.11 In what way does position effect variegation...Ch. 10 - 10.12 A pair of homologous chromosomes in...Ch. 10 - 10.13 An animal heterozygous for a reciprocal...Ch. 10 - Dr. Ara B. Dopsis has an idea he thinks will be a...Ch. 10 - A normal chromosome and its homolog carrying a...Ch. 10 - The accompanying chromosome diagram represents a...Ch. 10 - 10.17 Histone protein isolated from pea plants...Ch. 10 - 10.18 A survey of organisms living deep in the...Ch. 10 - In humans that XX/XO mosaics, the phenotype is...Ch. 10 - 10.20 A plant breeder would like to develop the...Ch. 10 - In Drosophilia, seven partial deletion (1to7)...Ch. 10 - Two experimental varieties of strawberry are...Ch. 10 - 10.23 In the tomato, Solanum esculentum, tall ()...Ch. 10 - A boy with Down syndrome (trisomy 21) has 46...Ch. 10 - Experimental evidence demonstrates that the...Ch. 10 - Prob. 26PCh. 10 - Genomic DNA from the nematode worm...Ch. 10 - 10.28 A small population of deer living on an...Ch. 10 - A eukaryote with a diploid number of 2n=6 carries...Ch. 10 - Prob. 30PCh. 10 - For the following crosses, determine as accurately...Ch. 10 - A healthy couple with a history of three previous...
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- The figure below shows a replicated homologous chromosome pair during meiosis where one of the chromosomes carries an inversion. Assume a crossover has occurred between D & E.arrow_forwardAn initial crossover event will occur between A and B, as indicated in the corresponding image. After this initial event occurs, a second crossover event occurs (not illustrated) involving the products of the first crossover event. a. Given this chromosome organization, A B c, A b c, a B C, and a b C, which two chromatids of the bivalent were involved chromatid 1 chromatid 2 chromatid 3 chromatid 4 and between which genes gene A gene B gene C did the second crossover event occur to produce the indicated chromosomes? b. Returning to the original crossover depicted in the image, given this chromosome organization, A B C, A B C, a b c, and a b c, which two chromatids of the bivalent were involved chromatid 1 chromatid 2 chromatid 3 chromatid 4 and between which genes gene A gene B gene C did the second crossover event occur to produce the indicated chromosomes?arrow_forwardTwo chromosomes have the ff. order of genes: Normal Abnormal A B C centromere DEFGHI A B G F E D centromere C H I (a) Does the abnormal chromosome have a pericentric or paracentric inversion? Why? (b) Draw a sketch to show how these two chromosomes would pair during synapsis, showing all four strands. In your sketch, assume crossing over has occurred between genes E and F. Illustrate the germ cells produced at the end of Meiosis II and describe these germ cells.arrow_forward
- Considering the following chromosome which is represented as a series of genes on each arm separated by the centromere. Describe the type of mutation required to produce each of the mutant chromosomes below. ABCDEFG*HIJKLMNarrow_forwardChromosome structural errors can occur during Meiosis which can lead to health disorders. Examine the figure below and select the correct order of error type from left to right in which they appear. duplicati on, translocation, deleti on, inversion duplication, inversion, del etion, translocation O deletion, translocati on, inversion, duplication O translocation, inversion, duplication, deletion inversion, translocation, duplication, deletionarrow_forwardwhy two crossovers are needed on one chromatid arm? explain pleasearrow_forward
- An individual heterozygous for a reciprocal translocation possesses the following chromosomes: A B ● C D E F G, A B • C D V W X, R S •T U E F G, R S•T U V W Xa. Draw the pairing arrangement of these chromosomes in prophase 1 of meiosis. Mention their gametic composition. b. Draw the alternate, adjacent I, and adjacent II segregation patterns in anaphase I of meiosis. Mention their gametic composition.arrow_forwardAn inversion heterozygote has the following inverted chromosome: Centromere ca a a A B CD JI HGF E, KL M Inverted region If a crossover occurred between genes H and I on one inverted and one normal chromosome, what would be the sequence of the dicentric chromosome before completion of metaphase I? A Cen B C D EFGHIJKL Cen M A Cen B C D JIHGFEKLM Cen JIH G F E Cen A Cen B C D JIHGFEDC B Cen A MLKEFGHIJKLMarrow_forwardFor questions 22 through 30, please refer to the pictures below: Normal B B B C D D D D' E E 22 23 24 B D G. Y D M H. B C E 25 26 27 28 B D Break through centromere B B A D 29 30 Identify the type of chromosomal aberration in each number above. Please refer to the choices below. Reciprocal translocation Robertsonian translocation Isochromosome Terminal deletion Interstitial deletion Duplication Pericentric inversion Ring chromosome Marker chromosome Paracentric inversionarrow_forward
- A diploid individual is heterozygous for a chromosome rearrangement. The original chromosome and its rearranged homolog have the following segments, where ∙ represents a centromere: A B ∙ C D E F G A B ∙ C F E D G While paired in prophase I, a single crossing-over occurs between segment E and segment D of the paired chromosomes. Describe the unusual crossing-over structure that forms as a result.What gamete types will result from crossing over when meiosis is complete? please asaparrow_forwardHere is a depiction of the position of several genes on 2 chromosomes, with a dash "-" depicting the position of the centromere. Chromosome A has genes ABCD-EFGHIJ Chromosome B has genes 1234-56789. Please name the kind of rearrangement that would result in the following derivative chromosomes: 12D-EFGHIJ AB4-56789 O Unbalanced reciprocal translocation Unbalanced nonreciprocal translocation Balanced reciprocal translocation Balanced nonreciprocal translocationarrow_forwardThe STR DNA marker DS11 is located on the p arm of the chromosome #8 in humans. Molecular analysis has shown that Charlie Chaplin is a heterozygote for the STR marker (genotype DS11A and DS11B) Using this knowledge, provide a diagram of meiosis showing only the movements of chromosome 8 (assume no nondisjunction). Throughout, indicate where the marker may be found (in other words, label the chromosome to show where the STR markers can be found. (Show ONLY the chromosomes at interphase, metaphase 1, end of meiosis 1, metaphase 2, and end of meiosis 2). Suppose Charlie conceived a son with a chromosome 8 trisomy. Molecular analysis of the STR DS11 marker revealed that his son carried two copies of the DS11A marker and a DS11C marker. Based on the data, determine if the nondisjunction occurred in Charlie or in the mother? Provide your reasoning.arrow_forward
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