Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 10, Problem 2P
The human genome contains contains
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A diploid human cell contains approximately 6.4 billion base pairs of DNA.
Assuming that the linker DNA encompasses 35 bp, how many nucleosomes are present in such a cell? Use two significant figures. How many histone proteins are complexed with this DNA? use two significant figures.
In not more than 200 words, explain how the human genome of 3.4 Gb would be in 2.3 meters long when stretched linearly if this size is fit into a cell of minuscule proportions.
A diploid organism with a 45,000-kb haploid genome contains 21% G residues. Calculate the number of A, C, G, and T residues in the DNA of each cell in this organism.
Chapter 10 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 10 - 10.1 Give descriptions for the following...Ch. 10 - 10.2 The human genome contains contains base...Ch. 10 - In eukaryotic DNA, Where are you most likely to...Ch. 10 - 10.4 Describe the importance of light and dark G...Ch. 10 - Human late prophase karyotypes have about 2000...Ch. 10 - Prob. 6PCh. 10 - From the following list, identify the types...Ch. 10 - 10.8 If the haploid number for a plant species is...Ch. 10 - Mating between a male donkey (2n=64) and a female...Ch. 10 - A researcher interested in studying a human gene...
Ch. 10 - 10.11 In what way does position effect variegation...Ch. 10 - 10.12 A pair of homologous chromosomes in...Ch. 10 - 10.13 An animal heterozygous for a reciprocal...Ch. 10 - Dr. Ara B. Dopsis has an idea he thinks will be a...Ch. 10 - A normal chromosome and its homolog carrying a...Ch. 10 - The accompanying chromosome diagram represents a...Ch. 10 - 10.17 Histone protein isolated from pea plants...Ch. 10 - 10.18 A survey of organisms living deep in the...Ch. 10 - In humans that XX/XO mosaics, the phenotype is...Ch. 10 - 10.20 A plant breeder would like to develop the...Ch. 10 - In Drosophilia, seven partial deletion (1to7)...Ch. 10 - Two experimental varieties of strawberry are...Ch. 10 - 10.23 In the tomato, Solanum esculentum, tall ()...Ch. 10 - A boy with Down syndrome (trisomy 21) has 46...Ch. 10 - Experimental evidence demonstrates that the...Ch. 10 - Prob. 26PCh. 10 - Genomic DNA from the nematode worm...Ch. 10 - 10.28 A small population of deer living on an...Ch. 10 - A eukaryote with a diploid number of 2n=6 carries...Ch. 10 - Prob. 30PCh. 10 - For the following crosses, determine as accurately...Ch. 10 - A healthy couple with a history of three previous...
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- For a linear B-DNA molecule of 50,000 kb, calculate (a) the contour length and (b) the length of the DNA as packaged in nucleosomes with linker histones present.arrow_forwardThe axial ratio is a term used to describe a rod-shaped molecule using the ratio of its length to its diameter. Given that the standard conformation of DNA in a physiological solution has a diameter of 2.37 nm, what is the axial ratio of the longest chromosome of Drosophila melanogaster DNA, which is 21000 µm long? Please record your answer in scientific notation. axial ratio: x10arrow_forwardGiven the fact that 1 fg of DNA = 9.78 * 105base pairs (on average), you can convert the amount of DNA per cell to the lengthof DNA in numbers of base pairs. (a) Calculate the number of basepairs of DNA in the haploid yeast genome. Express your answer inmillions of base pairs (Mb), a standard unit for expressing genomesize. Show your work. (b) How many base pairs per minute weresynthesized during the S phase of these yeast cells?arrow_forward
- The diploid human genome comprises 6,4 * 10^9 bp and fits into a nucleus that is 6 μm in diameter. If base pairs occur at intervals of 0.34 nm along the DNA helix, what is the length of DNA in a human cell If the diameter of the DNA helix is 2,4 nm, what fraction of the volume of the nucleus is occupied by DNA? [volume of a sphere is (4/3)πr^3 and volume of a cylinder is πr^2h]arrow_forwardRice genome contains 30% C on a molar basis. What are the mole percentages of A, G, and T?arrow_forwardA diploid human cell contains approximately 6.4 billion base pairs of DNA. a. How many nucleosomes are present in such a cell? (Assume that the linker DNA encompasses 40 bp.) b. How many histone proteins are complexed with this DNA?arrow_forward
- Below is a sequence of 540 bases from a genome. What information would you use to find the beginnings and ends of open reading frames? How many open reading frames can you find in this sequence? Which open reading frame is likely to represent a protein- coding sequence, and why? Which are probably not functioning protein-coding sequences, and why? Note: for simplicitys sake, analyze only this one strand of the DNA double helix, reading from left to right, so you will only be analyzing three of the six reading frames shown in Figure 19.4.arrow_forwardYou are studying a large eukaryotic gene that is 439,515 base pairs long. You find the polypeptide that this gene produces in liver cells is 46,771 amino acids long. Your colleague studies the function of this gene in brain cells, and finds the polypeptide produced in the brain is much larger – 61,438 amino acids long. How do you explain this difference? Possible Answers: A. The cell cycle of liver cells is much longer than that of brain cells. B. This is due to alternative splicing. in the brain C. There was a different complement of sequence-specific transcription factor binding sites in the CRM of the brain cells. D. There is no 5' cap added to the gene product from the liver cells.arrow_forwardOne gram of cultured human cells contains about 109 cells and occupies roughly 1 mL. If the average molecular mass of a base pair is 660 daltons and each cell contains 6.4 x 109 bp, what mass of DNA is present in this one-gram sample? If all the DNA molecules in the sample were laid end to end to form a single thread, would it be long enough to reach from the Earth to the Moon (385,000 kilometers)?arrow_forward
- The DNA sequence of the genome of a virus is known and contains equal number of A, TG and C. The genome is composed of double stranded DNA molecule. It is 10Kb in length. If one searches the genome for the presence of the following sequence 5'-AAAAAA-3'/3'-TTTTTT-5', predict the number of such stretches that are likely to occur. (1Kb = 1000 base pairs). a) Two b) Eight c) Sixteen d) Thirty twoarrow_forwardThe diploid human genome comprises 6.4 x 10° bp and fits into a nucleus that is 6 um in diameter: If base pairs occur at intervals of 0.34 nm along the DNA helix, what is the (i) length of DNA in the human cell? (ii) If the diameter of the DNA helix is 2.4 nm, what fraction of the volume of the nucleus is occupied by DNA?arrow_forwardOne gram of cultured human cells contains about 10^9 cells and occupies roughly 1 mL. if the average molecular mass of a base is 660 daltons and each cell contains 6,4 *10^9 bp, what mass of DNA is present in this one-gram sample? If all the DNA molecules in the sample were laid end to end to form a single thread. Would it be long enough to reach from the Earth to the Moon (385.000 kilometers).arrow_forward
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