Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN: 9781305073951
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 10, Problem 2DAA
Summary Introduction
To determine: The trend shown in the data that is seen around the age of 9 years.
Concept introduction: The eating behavior was evolved in order to meet the requirements for the growth and health of the person. The parental eating behavior has a great influence on the mortality rate of the offspring. The survival of the humans greatly affects the food scarcity.
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The introduction to this chapter describes the long-term effects of famine on people conceived during the Dutch Hunger Winter. a. What evidence suggests that these are epigenetic effects? b. What additional evidence would help to demonstrate that these changes are due to epigenetic changes?
Considerable effort has been directed toward determining the genes in which sequence variation contributes to the development of type 2 diabetes. Approximately 800 genes have been implicated. Propose an explanation for this observation.
Comparisons between human and chimpanzee genomes indicate that a gene that may function as a wild-type or normal gene in one primate may function as a disease-causing gene in another [The Chimpanzee Sequencing and Analysis Consortium (2005). Nature 437:69–87]. For instance, the PPARG locus (regulator of adipocyte differentiation) is a wild-type allele in chimps but is clearly associated with Type 2 diabetes in humans. What factors might cause this apparent contradiction? Would you consider such apparent contradictions to be rare or common? What impact might such findings have on the use of comparative genomics to identify and design therapies for disease-causing genes in humans?
Chapter 10 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 10 - The expression of a gene may depend on _______. a....Ch. 10 - Prob. 2SQCh. 10 - Binding of ______ to _______ in DNA can increase...Ch. 10 - Prob. 4SQCh. 10 - Prob. 5SQCh. 10 - Muscle cells differ from bone cells because...Ch. 10 - Prob. 7SQCh. 10 - Homeotic gene products _______. a. flank a...Ch. 10 - A gene that is knocked out is ________. a. deleted...Ch. 10 - Which of the following includes all of the others?...
Ch. 10 - Prob. 11SQCh. 10 - Effect of Paternal Grandmothers Food Supply on...Ch. 10 - Prob. 2DAACh. 10 - Effect of Paternal Grandmothers Food Supply on...Ch. 10 - Prob. 12SQCh. 10 - A cell with a Barr body is ___ . a. a bacterium b....Ch. 10 - Operons _____. a. only occur in bacteria b. have...Ch. 10 - Prob. 15SQCh. 10 - Why are some genes expressed and some not?Ch. 10 - Prob. 2CTCh. 10 - Almost all calico cats (one is pictured in FIGURE...Ch. 10 - The photos above show flowers from Arabidopsis...
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- A/a O A"/a afa Q afa Q Unsupplemented Supplemented b A"/a offspring Unsupplemented mother Supplemented mother This question relates to the aqouti mice research discussed in the lecture. What did the researchers observe in the experimental group (AVYA x aa) that was fed diets high in methyl donors? They gained weight rapidly. Increased expression of aqouti gene. Reduced risk of chronic disease Higher percentage of yellow offspring.arrow_forwardhttp://www.letsgethealthy.org/students/games/epigenetics-game/ (Links to an external site.) For the assignment this week I want you to play this epigenetic game that will show you how your choices (which will be the equivalent of of external factors in someone life) make your genes act differently. Last week, we learned about biology and race and how these fit together in the formation of biological determinants and social misconceptions. For this week's discussion, play the game. Discuss with your classmates what happened, and what you have learned about epigenetics and how this changes your understanding of genetics . How do epigenetic changes and epigenetic mechanisms in general influence health, our concepts of race, and inequality?arrow_forwardThe introduction to this chapter describes the long-term effects of famine on people conceived during the Dutch Hunger Winter. Q. What evidence suggests that these are epigenetic effects?arrow_forward
- Studies on monkeys have provided insight on the role of maternal care on the epigenome. Imagine you have 3 groups of monkeys. Group A: Monkeys raised by their biological mother. Group B: Monkeys raised by other monkeys that are not their biological mother. Group C: Monkeys raised by a human surrogate nurse. You then study the behavioural and epigenetic patterns of these monkeys. Which of the findings would be plausible from this study? A. Monkeys from group A will most likely become alcoholics. B. Monkeys from group B will be equally anxious compared to group C since neither were raised by their biological mother. C. Monkeys from group C will have a significantly different epigenomic pattern compared to group A. D. Groups A, B and C will have similar epigenomic patterns.arrow_forwardEpigenetics may be partially responsible for the childhood epidemic of obesity. Explain.arrow_forwardOur understanding of maternal effect genes has been greatly aided by their identification in experimental organisms such as Drosophila melanogaster and Caenorhabditis elegans. In experimental organisms with a short generation time, geneticists have successfully searched for mutant alleles that prevent the normal process of embryonic development. In many cases, the offspring die at early embryonic or larval stages. These are called maternal effect lethal alleles. How would a researcher identify a mutation that produced a recessive maternal effect lethal allele?arrow_forward
- Through GWAS explorations, scientists have identified several SNPs linked to obesity in people who livein the United States. One of these SNPs was within agene called FTO. Interestingly, a common FTO variant is associated with obesity, but only in people bornafter 1945. Moreover, the later the birth year, thehigher the risk for obesity associated with this variantof FTO. Why would a genetic risk factor for obesityvary by birth year?arrow_forward23arrow_forwardAPOE gene has been found to be a major contributor to sporadic Alzheimer's disease (AD), by acting as an age-of-onset modifier for the common relatively late-onset forms of the disease. Among four alleles causing early onset of AD, the epsilon4 allele (APOE4) disrupts this function. If you generate transgenic monkeys in which the normal allele of APOE gene is knocked out, what phenotype will you expect for those knockout monkeys? A. The APE mRNA expression will be completely suppressed. B. They slow down the development of AD. C. They develop AD early. D. They don't show any AD symptom.arrow_forward
- Which of the following best explains how individuals who inherit phenylketonuria alleles can avoid the symptoms of this disease (mental impairment, foul smelling urine)? It exhibits variable expressivity. The expression of this disease depends on the environment. If the individual removes phenylalanine from their diet they can avoid the disease entirely. PKU alleles are epistatic to alleles of another gene, which acts downstream in phenylalanine metabolism. These individuals supplement their diets with enzymes that break-down phenylalanine.arrow_forwardAurora AAurora A is a protein that acts as a kinase (transfers phosphates to molecules). Many types of cancer cells, including breast cancer cells, have higher than normal levels of this protein.Expressions of Aurora A genes in normal breast tissues (n = 10), normal tissues adjacent to tumors (n = 12) and breast tumors (n = 14).Scientists studying the production of Aurora A protein in normal frog cells observed that the amount of this protein in the cells changed throughout the cell cycle.Scientists tested chemicals that block Aurora 2 to see if they could be used as anti-cancer drugs. They found that some of the candidate drugs did slow the growth of cancer cells in cell culture in the lab. But when they tested these drugs in cancer patients to see if the drugs could slow the growth of solid tumors, they found that the benefit to patients was small when compared to the development of severe side effects such as anemia (low red blood cell count) and leukopenia (low white blood cell…arrow_forwardBoll weevil is a serious pest of cotton crop. Effective control involves applications of chemical insecticides, increasing the cost of production and environmental pollution. The current genetically modified Bt crops have allowed great benefits to farmers but show activity limited to lepidopteran pests. This work reports on procedures adopted for integration and expression of a cry transgene conferring resistance to boll weevil and fall armyworm by using molecular tools. Four Brazilian cotton cultivars were microinjected with a minimal linear cassette generating 1248 putative lines. Complete gene integration was found in only one line (TO-34) containing one copy of crylla detected by Southern blot. Protein was expressed in high concentration at 45 davs after emergence (dae), decreasing by approximately 50% at 90 dae. Toxicity of the cry protein was demonstrated in feeding bioassays revealing 56.7% mortality to boll weevil fed buds and 88.1% mortality to fall armyworm fed leaves. A…arrow_forward
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