Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN: 9781305073951
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 10, Problem 1DAA
Effect of Paternal Grandmother’s Food Supply on Infant Mortality Researchers are investigating long- reaching epigenetic effects of starvation, in part because historical data on periods of famine are widely available. Before the industrial revolution, a failed harvest in one autumn typically led to severe food shortages the following winter. A retrospective study has correlated female infant mortality at certain ages with the abundance of food during the paternal grandmother’s childhood. FIGURE 10.12 shows some of the results of this study.
FIGURE 10.12 Graph showing the relative risk of early death of a female child, correlated with the age at which her paternal grandmother experienced a winter with a food supply that was scarce (blue) or abundant (red) during childhood. The dotted line represents no difference in risk of morality. A value above the line means an increases risk; one below the line indicates a reduced risk.
1. Compare the mortality of girls whose paternal grandmothers ate well at age 2 with that of those who experienced famine at the same age. Which girl was more likely to die early? How much more likely was she to die?
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Based on the information from studies of the long-term effects of diet on metabolism in mice, what might the epigenetic effects be on the children and grandchildren of people who were exposed to famine as children? Include in your answer the types of epigenetic changes in chromatin that you might expect to see and the phenotypic effects on lipid and cholesterol metabolism
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increased maternal care during childhood resulted in lower stress levels as adults and decreased maternal care with their own offspring.
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Increased maternal care during childhood resulted in higher stress levels as adults and decreased maternal care with their own offspring.
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Comparisons between human and chimpanzee genomes indicate that a gene that may function as a wild-type or normal gene in one primate may function as a disease-causing gene in another [The Chimpanzee Sequencing and Analysis Consortium (2005). Nature 437:69–87]. For instance, the PPARG locus (regulator of adipocyte differentiation) is a wild-type allele in chimps but is clearly associated with Type 2 diabetes in humans. What factors might cause this apparent contradiction? Would you consider such apparent contradictions to be rare or common? What impact might such findings have on the use of comparative genomics to identify and design therapies for disease-causing genes in humans?
Chapter 10 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 10 - The expression of a gene may depend on _______. a....Ch. 10 - Prob. 2SQCh. 10 - Binding of ______ to _______ in DNA can increase...Ch. 10 - Prob. 4SQCh. 10 - Prob. 5SQCh. 10 - Muscle cells differ from bone cells because...Ch. 10 - Prob. 7SQCh. 10 - Homeotic gene products _______. a. flank a...Ch. 10 - A gene that is knocked out is ________. a. deleted...Ch. 10 - Which of the following includes all of the others?...
Ch. 10 - Prob. 11SQCh. 10 - Effect of Paternal Grandmothers Food Supply on...Ch. 10 - Prob. 2DAACh. 10 - Effect of Paternal Grandmothers Food Supply on...Ch. 10 - Prob. 12SQCh. 10 - A cell with a Barr body is ___ . a. a bacterium b....Ch. 10 - Operons _____. a. only occur in bacteria b. have...Ch. 10 - Prob. 15SQCh. 10 - Why are some genes expressed and some not?Ch. 10 - Prob. 2CTCh. 10 - Almost all calico cats (one is pictured in FIGURE...Ch. 10 - The photos above show flowers from Arabidopsis...
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